Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.49 |
| ▸ | HTR1E | P28566 | 2/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | NPY2R | P49146 | 3/20 | 0.48 |
| ▸ | MTTP | P55157 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5049558 | 0.87 | HTR1E (0.64) | HTR1ES1PR3MEN1LMNAMAPT | |
| SCHEMBL5049482 | 0.86 | CYP1A2 (0.63) | HTR1ES1PR3MEN1LMNAMAPT | |
| SCHEMBL6994952 | 0.83 | SLC6A2 (0.43) | SMYD3OPRD1MEN1LMNAKMT2A | |
| SCHEMBL5077966 | 0.81 | KDM4E (0.53) | TP53CYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL4678502 | 0.81 | SLC6A3 (0.60) | SMYD3OPRD1HTR1ES1PR3MEN1 | |
| SCHEMBL8193192 | 0.79 | SLC6A2 (0.65) | SMYD3OPRD1PKMLMNAMAPT | |
| SCHEMBL13114874 | 0.79 | CACNA2D1 (0.50) | SMYD3OPRD1HTR1ES1PR3MEN1 | |
| SCHEMBL4537372 | 0.78 | SLC6A3 (0.64) | SMYD3LMNAKMT2ATSHRTDP1 | |
| SCHEMBL5838596 | 0.77 | ADRA2A (0.50) | — | |
| SCHEMBL6528518 | 0.76 | CACNA2D1 (0.48) | SMYD3OPRD1HTR1ES1PR3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101080387-A | Process for the preparation of N- (4-piperidinyl) -N-ethyl-phenylacetamides from N-tert-butoxycarbonyl-4-oxopiperidine | ASTRAZENECA AB (SE) | 2007-11-28 | — | — | CN | claimed |
| US-8183239-B2 | Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2012-05-22 | — | — | US | disclosed |
| EP-1948629-A1 | SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007053436-A1 | SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-10 | — | — | WO | disclosed |
| US-20070100141-A1 | SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070100141-A1 | SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR | NPY2R, NPY5R, NPY4R | SMYD3 1978/4885OPRD1 120/4885HTR1E 95/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.