SCHEMBL5083753

SCHEMBL5083753

FC(F)(F)c1cc(P(c2cc(C(F)(F)F)cc(C(F)(F)F)c2)c2ccc3ccccc3c2-c2cccc3ccccc23)cc(C(F)(F)F)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RX1 P51575 1/20 0.36
P2RX3 P56373 1/20 0.36
P2RX4 Q99571 1/20 0.36
P2RX7 Q99572 1/20 0.36
KCNQ3 O43525 3/20 0.36
KCNQ2 O43526 3/20 0.36
PSD A5PKW4 1/20 0.36
HSD11B1 P28845 1/20 0.33
CYP1A2 P05177 2/20 0.33
CYP1A1 P04798 1/20 0.33
CYP1B1 Q16678 1/20 0.33
DNMT1 P26358 1/20 0.33
KDM4E B2RXH2 3/20 0.32
MAPT P10636 2/20 0.32
NFKB1 P19838 1/20 0.32
NFKB2 Q00653 1/20 0.32
RELA Q04206 1/20 0.32
HPGD P15428 1/20 0.32
CNR2 P34972 1/20 0.32
GPR84 Q9NQS5 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7798355 0.91 CYP1A2 (0.37) KCNQ3KCNQ2PSDHSD11B1CYP1A2
SCHEMBL30391892 0.90 P2RX1 (0.40) P2RX1P2RX3P2RX4P2RX7CYP1A2
SCHEMBL2229892 0.90 P2RX1 (0.40) P2RX1P2RX3P2RX4P2RX7CYP1A2
SCHEMBL8615377 0.88 P2RX1 (0.39) P2RX1P2RX3P2RX4P2RX7PSD
SCHEMBL7796059 0.88 KCNQ3 (0.34) KCNQ3KCNQ2PSDHSD11B1DNMT1
SCHEMBL30616088 0.86 KCNQ3 (0.34) P2RX1P2RX3P2RX4P2RX7KCNQ3
SCHEMBL8611244 0.83 P2RX1 (0.41) P2RX1P2RX3P2RX4P2RX7CYP1A2
SCHEMBL8613773 0.81 P2RX1 (0.39) P2RX1P2RX3P2RX4P2RX7KDM4E
SCHEMBL5080119 0.80 DHFR (0.40) CYP1A2DNMT1KDM4EMAPTHPGD
SCHEMBL275907 0.79 DNMT1 (0.40) DNMT1KDM4EMAPTNFKB1NFKB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2007703-A1 METAL COMPLEXES FOR USE IN THE CARBONYLATION OF ETHYLENICALLY UNSATURATED COMPOUNDS Lucite International UK Limited (GB) 2008-12-31 EP disclosed
WO-2007119079-A1 METAL COMPLEXES FOR USE IN THE CARBONYLATION OF ETHYLENICALLY UNSATURATED COMPOUNDS LUCITE INTERNATIONAL UK LIMITED (GB) 2007-10-25 WO disclosed
EP-0731105-B1 Optically active tertiary phosphine compounds, transition metal complexes comprising the same as ligands and process for preparing optically active organic silicon compounds using said transition metal complexes SUMITOMO CHEMICAL CO (JP) 2001-12-05 EP disclosed
US-5621129-A Optically active tertiary phosphine compound, transition metal complex comprising the same as ligand and process for preparing optically active organic silicon compound using said transition metal complex SUMITOMO CHEMICAL CO., LTD. (JP) 1997-04-15 US disclosed
EP-0731105-A1 Optically active tertiary phosphine compounds, transition metal complexes comprising the same as ligands and process for preparing optically active organic silicon compounds using said transition metal complexes SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-09-11 EP disclosed