SCHEMBL7796059

SCHEMBL7796059

FC(F)(F)c1ccc(P(c2ccc(C(F)(F)F)cc2)c2ccc3ccccc3c2-c2cccc3ccccc23)cc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNQ3 O43525 3/20 0.34
KCNQ2 O43526 3/20 0.34
PSD A5PKW4 1/20 0.34
CNR2 P34972 1/20 0.34
HSD11B1 P28845 1/20 0.34
KCNJ11 Q14654 1/20 0.34
DNMT1 P26358 1/20 0.33
SIRT2 Q8IXJ6 1/20 0.33
MAPT P10636 2/20 0.33
MEN1 O00255 1/20 0.33
LMNA P02545 1/20 0.33
HTT P42858 1/20 0.33
KMT2A Q03164 1/20 0.33
SLC6A4 P31645 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
ENPP1 P22413 1/20 0.32
DHFR P00374 1/20 0.32
KIF11 P52732 1/20 0.32
ALDH1A1 P00352 1/20 0.32
TSHR P16473 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6930336 0.90 CNR2 (0.38) CNR2KCNJ11MAPTSLC6A4L3MBTL1
SCHEMBL5083753 0.88 P2RX1 (0.36) KCNQ3KCNQ2PSDCNR2HSD11B1
SCHEMBL301186 0.87 ALDH1A1 (0.38) CNR2KCNJ11MAPTSLC6A4L3MBTL1
SCHEMBL7798355 0.86 CYP1A2 (0.37) KCNQ3KCNQ2PSDCNR2HSD11B1
SCHEMBL9681504 0.86 HSP90AA1 (0.39) KCNQ3KCNQ2DNMT1MAPTMEN1
SCHEMBL7796060 0.84 DNMT1 (0.36) DNMT1MAPTMEN1KMT2AL3MBTL1
SCHEMBL30616100 0.84 DNMT1 (0.40) DNMT1MAPTMEN1LMNAKMT2A
SCHEMBL29368065 0.84 DNMT1 (0.40) DNMT1MAPTMEN1LMNAKMT2A
SCHEMBL275907 0.84 DNMT1 (0.40) DNMT1MAPTMEN1LMNAKMT2A
SCHEMBL8595804 0.82 DNMT1 (0.39) DNMT1MAPTMEN1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0731105-B1 Optically active tertiary phosphine compounds, transition metal complexes comprising the same as ligands and process for preparing optically active organic silicon compounds using said transition metal complexes SUMITOMO CHEMICAL CO (JP) 2001-12-05 EP disclosed
EP-0731105-A1 Optically active tertiary phosphine compounds, transition metal complexes comprising the same as ligands and process for preparing optically active organic silicon compounds using said transition metal complexes SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1996-09-11 EP disclosed