SCHEMBL5086008

SCHEMBL5086008

O=C(O)c1ccc(Oc2ccc(Sc3ccccc3Oc3cccc(C(=O)O)c3C(=O)O)cc2)cc1C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.48
PYGL P06737 8/20 0.44
HPSE Q9Y251 1/20 0.43
PYGM P11217 9/20 0.42
TDP1 Q9NUW8 2/20 0.42
GALK1 P51570 1/20 0.42
CASP6 P55212 1/20 0.42
MCL1 Q07820 1/20 0.42
PLEC Q15149 1/20 0.42
SIRT2 Q8IXJ6 1/20 0.39
SIRT1 Q96EB6 1/20 0.39
MAPK1 P28482 1/20 0.38
GFER P55789 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
LMNA P02545 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL420308 0.89 POLB (0.50) POLBPYGLHPSEPYGMTDP1
SCHEMBL11060851 0.85 SIRT1 (0.47) POLBTDP1SIRT1MAPK1MEN1
SCHEMBL3854639 0.84 PYGL (0.52) POLBPYGLHPSEPYGMTDP1
SCHEMBL422032 0.84 POLB (0.57) POLBPYGLHPSEPYGMTDP1
SCHEMBL11669603 0.82 APEX1 (0.44) POLBHPSETDP1GALK1CASP6
SCHEMBL716921 0.81 PYGL (0.53) POLBPYGLHPSEPYGMTDP1
SCHEMBL29404149 0.81 PYGL (0.53) POLBPYGLHPSEPYGMTDP1
SCHEMBL3417323 0.80 TDP1 (0.54) POLBPYGLHPSEPYGMTDP1
SCHEMBL425870 0.80 CTNNB1 (0.42) POLBHPSETDP1MAPK1MEN1
SCHEMBL11669736 0.80 SIRT1 (0.42) POLBSIRT1MAPK1GFER

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1940957-A1 LOW SMOKE POLYCARBONATE COMPOSITION AND LAMINATES, METHOD OF MANUFACTURE AND PRODUCT MADE THEREFROM General Electric Company (US) 2008-07-09 EP disclosed
WO-2007024456-A1 LOW SMOKE POLYCARBONATE COMPOSITION AND LAMINATES, METHOD OF MANUFACTURE AND PRODUCT MADE THEREFROM GENERAL ELECTRIC COMPANY (US) 2007-03-01 WO disclosed
EP-1448672-A1 HIGH MOLECULAR WEIGHT POLY(IMIDE)S AND METHODS OF SYNTHESIS THEREOF GENERAL ELECTRIC COMPANY (US) 2004-08-25 EP disclosed
EP-1301341-A4 POLYMER COATINGS MICROCOATING TECHNOLOGIES INC (US) 2004-07-14 EP disclosed
WO-2003040213-A1 HIGH MOLECULAR WEIGHT POLY(IMIDE)S AND METHODS OF SYNTHESIS THEREOF GENERAL ELECTRIC COMPANY (US) 2003-05-15 WO disclosed
EP-1301341-A1 POLYMER COATINGS MicroCoating Technologies, Inc. (US) 2003-04-16 EP disclosed
WO-2002002320-A1 POLYMER COATINGS MICROCOATING TECHNOLOGIES, INC. (US) 2002-01-10 WO disclosed
EP-1124891-A1 POLYETHERIMIDE RESIN/POLYESTER RESIN BLENDS GENERAL ELECTRIC COMPANY (US) 2001-08-22 EP disclosed
WO-2000012604-A1 POLYETHERIMIDE RESIN/POLYESTER RESIN BLENDS GENERAL ELECTRIC COMPANY (US) 2000-03-09 WO disclosed