Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30193187 | 0.82 | LMNA (0.50) | P2RX7KDM4ECYP1A2LMNAL3MBTL1 | |
| SCHEMBL874090 | 0.81 | CYP1A2 (0.50) | P2RX7KDM4EMAPTCYP1A2LMNA | |
| SCHEMBL77616 | 0.79 | HTT (0.48) | P2RX7KDM4EMAPTCYP1A2CES2 | |
| SCHEMBL7769482 | 0.79 | P2RX7 (0.38) | P2RX7KDM4EMAPTCYP1A2CES2 | |
| SCHEMBL1719924 | 0.79 | LMNA (0.47) | P2RX7KDM4EMAPTCYP1A2CES2 | |
| SCHEMBL8539040 | 0.79 | P2RX7 (0.38) | P2RX7KDM4EMAPTCYP1A2CES2 | |
| Hydrochloric Acid SCHEMBL6645397 | 0.79 | KDM4E (0.48) | P2RX7KDM4EMAPTCYP1A2LMNA | |
| SCHEMBL1483489 | 0.74 | HTT (0.42) | P2RX7LMNAGAAHTTALDH1A1 | |
| SCHEMBL1483401 | 0.74 | KDM4E (0.41) | P2RX7KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13819944 | 0.74 | CYP1A2 (0.47) | P2RX7KDM4EMAPTCYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1440064-B1 | PROCESS FOR THE PREPARATION OF (PYRIMIDIN-2-YL)METHYL KETONES | LONZA AG (CH) | 2008-05-07 | — | — | EP | claimed |
| US-7145007-B2 | Process for the preparation of (pyrimidin-2-yl) methyl ketones | LONZA LTD. (CH) | 2006-12-05 | — | — | US | claimed |
| US-20040242876-A1 | Process for the preparation of (pyrimmidin-2-yl) methyl ketones | LONZA LTD. (CH) | 2004-12-02 | — | — | US | claimed |
| EP-1440064-A1 | PROCESS FOR THE PREPARATION OF (PYRIMMIDIN-2-YL)METHYL KETONES | LONZA LTD. (CH) | 2004-07-28 | — | — | EP | claimed |
| WO-2003033474-A1 | PROCESS FOR THE PREPARATION OF (PYRIMMIDIN-2-YL)METHYL KETONES | LONZA LTD. (CH) | 2003-04-24 | — | — | WO | claimed |
| EP-1440064-B1 | PROCESS FOR THE PREPARATION OF (PYRIMIDIN-2-YL)METHYL KETONES | LONZA AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| EP-1440064-B1 | PROCESS FOR THE PREPARATION OF (PYRIMIDIN-2-YL)METHYL KETONES | LONZA AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-7145007-B2 | Process for the preparation of (pyrimidin-2-yl) methyl ketones | LONZA LTD. (CH) | 2006-12-05 | — | — | US | disclosed |
| US-7145007-B2 | Process for the preparation of (pyrimidin-2-yl) methyl ketones | LONZA LTD. (CH) | 2006-12-05 | — | — | US | disclosed |
| CN-1262545-C | Process for preparing (pyrimidin-2-yl) methyl ketones | LONZA AG (CH) | 2006-07-05 | — | — | CN | disclosed |
| CN-1262545-C | Process for preparing (pyrimidin-2-yl) methyl ketones | LONZA AG (CH) | 2006-07-05 | — | — | CN | disclosed |
| CN-1571773-A | Process for preparing (pyrimidin-2-yl) methyl ketones | LONZA AG (CH) | 2005-01-26 | — | — | CN | disclosed |
| CN-1571773-A | Process for preparing (pyrimidin-2-yl) methyl ketones | LONZA AG (CH) | 2005-01-26 | — | — | CN | disclosed |
| US-20040242876-A1 | Process for the preparation of (pyrimmidin-2-yl) methyl ketones | LONZA LTD. (CH) | 2004-12-02 | — | — | US | disclosed |
| US-20040242876-A1 | Process for the preparation of (pyrimmidin-2-yl) methyl ketones | LONZA LTD. (CH) | 2004-12-02 | — | — | US | disclosed |
| EP-1440064-A1 | PROCESS FOR THE PREPARATION OF (PYRIMMIDIN-2-YL)METHYL KETONES | LONZA LTD. (CH) | 2004-07-28 | — | — | EP | disclosed |
| EP-1440064-A1 | PROCESS FOR THE PREPARATION OF (PYRIMMIDIN-2-YL)METHYL KETONES | LONZA LTD. (CH) | 2004-07-28 | — | — | EP | disclosed |
| WO-2003033474-A1 | PROCESS FOR THE PREPARATION OF (PYRIMMIDIN-2-YL)METHYL KETONES | LONZA LTD. (CH) | 2003-04-24 | — | — | WO | disclosed |
| WO-2003033474-A1 | PROCESS FOR THE PREPARATION OF (PYRIMMIDIN-2-YL)METHYL KETONES | LONZA LTD. (CH) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040242876-A1 | Process for the preparation of (pyrimmidin-2-yl) methyl ketones | MRM1, CYP2E1, CBR1 | P2RX7 3547/4885KDM4E 220/4885MAPT 4518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.