Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5094342 | 0.79 | P2RX7 (0.41) | P2RX7KDM4EMAPTCYP1A2CES2 | |
| SCHEMBL874090 | 0.77 | CYP1A2 (0.50) | P2RX7KDM4EMAPTCYP1A2LMNA | |
| SCHEMBL8539040 | 0.75 | P2RX7 (0.38) | P2RX7KDM4EMAPTCYP1A2CES2 | |
| SCHEMBL1719924 | 0.75 | LMNA (0.47) | P2RX7KDM4EMAPTCYP1A2CES2 | |
| SCHEMBL77616 | 0.75 | HTT (0.48) | P2RX7KDM4EMAPTCYP1A2CES2 | |
| Hydrochloric Acid SCHEMBL6645397 | 0.75 | KDM4E (0.48) | P2RX7KDM4EMAPTCYP1A2LMNA | |
| SCHEMBL1258953 | 0.73 | RAB9A (0.54) | CYP1A2SMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL536418 | 0.70 | P2RX7 (0.35) | P2RX7KDM4EMAPTCYP1A2LMNA | |
| SCHEMBL13564586 | 0.70 | LMNA (0.33) | KDM4ELMNAHTTALDH1A1 | |
| SCHEMBL1483489 | 0.70 | HTT (0.42) | P2RX7LMNAGAAHTTPSMB8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0765879-B1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO CO (JP) | 2001-02-14 | — | — | EP | disclosed |
| US-5861429-A | MITICIDES AND ANTHELMINTICS | SANKYO COMPANY, LIMITED (JP) | 1999-01-19 | — | — | US | disclosed |
| EP-0765879-A1 | 13-Substituted milbemycin 5-oxime derivatives, their preparation and their use against insects and other pests | SANKYO COMPANY LIMITED (JP) | 1997-04-02 | — | — | EP | disclosed |