Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30193187 | 0.82 | LMNA (0.50) | LMNAHTTALDH1A1CYP1A2TSHR | |
| SCHEMBL5094342 | 0.79 | P2RX7 (0.41) | LMNAHTTALDH1A1CYP1A2TSHR | |
| SCHEMBL2948061 | 0.79 | P2RX7 (0.36) | LMNAHTTALDH1A1CYP1A2TSHR | |
| SCHEMBL28182827 | 0.78 | ALDH1A1 (0.34) | LMNAHTTALDH1A1P2RX7L3MBTL1 | |
| SCHEMBL874090 | 0.77 | CYP1A2 (0.50) | LMNAHTTALDH1A1CYP1A2TSHR | |
| SCHEMBL28435181 | 0.76 | ALDH1A1 (0.48) | LMNAHTTALDH1A1CYP1A2TSHR | |
| SCHEMBL13564586 | 0.75 | LMNA (0.33) | LMNAHTTALDH1A1KDM4E | |
| SCHEMBL7769482 | 0.75 | P2RX7 (0.38) | LMNAHTTALDH1A1CYP1A2TSHR | |
| Hydrochloric Acid SCHEMBL6645397 | 0.75 | KDM4E (0.48) | LMNAHTTALDH1A1CYP1A2TSHR | |
| SCHEMBL77616 | 0.75 | HTT (0.48) | HTTCYP1A2P2RX7KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1334968-B1 | PROCESS FOR PRODUCING SUBSTITUTED ANILINE COMPOUND | IHARA CHEMICAL IND CO (JP) | 2012-01-11 | — | — | EP | claimed |
| EP-2025665-B1 | Process for producing substituted aniline compound | IHARA CHEMICAL IND CO (JP) | 2010-09-15 | — | — | EP | claimed |
| US-7521555-B2 | Process for producing substituted aniline compound | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2009-04-21 | — | — | US | claimed |
| US-7504503-B2 | Process for producing substituted aniline compound | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2009-03-17 | — | — | US | claimed |
| EP-2025665-A1 | Process for producing substituted aniline compound | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 2009-02-18 | — | — | EP | claimed |
| EP-1440063-B1 | PROCESS FOR THE PREPARATION OF 1-(PYRIMIDIN-2-YL)PROPAN-2-ONES | LONZA AG (CH) | 2008-03-12 | — | — | EP | claimed |
| US-20070213533-A1 | Process for producing substituted aniline compound | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2007-09-13 | — | — | US | claimed |
| US-20060281765-A1 | Process for producing substituted aniline compound | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 2006-12-14 | — | — | US | claimed |
| US-7141670-B2 | Process for the preparation of 1-(pyrimidin-2-yl)propan-2-ones | LONZA LTD. (CH) | 2006-11-28 | — | — | US | claimed |
| US-20040242877-A1 | Process for the preparation of 1-(pyrimidin-2-yl) Propan-2-ones | IHARA CHEMICAL INDUSTRY CO., LTD (JP) | 2004-12-02 | — | — | US | claimed |
| EP-1440063-A1 | PROCESS FOR THE PREPARATION OF 1-(PYRIMIDIN-2-YL)PROPAN-2-ONES | LONZA LTD. (CH) | 2004-07-28 | — | — | EP | claimed |
| US-20040034251-A1 | Process for production of substituted aniline compound | 1HARA CHEMICAL INDUSTRY CO., LT.D. (JP) | 2004-02-19 | — | — | US | claimed |
| EP-1334968-A1 | PROCESS FOR PRODUCING SUBSTITUTED ANILINE COMPOUND | Ihara Chemical Industry Co., Ltd. (JP) | 2003-08-13 | — | — | EP | claimed |
| WO-2003033475-A1 | PROCESS FOR THE PREPARATION OF 1-(PYRIMIDIN-2-YL)PROPAN-2-ONES | LONZA LTD. (CH) | 2003-04-24 | — | — | WO | claimed |
| EP-0347866-B1 | ANILINOPYRIMIDINE DERIVATIVES | IHARA CHEMICAL INDUSTRY Co., Ltd. (JP) | 1993-04-07 | — | — | EP | claimed |
| EP-3793565-B1 | MCL-1 INHIBITORS | GILEAD SCIENCES INC (US) | 2022-01-05 | — | — | EP | disclosed |
| EP-3101013-B1 | FUSED BENZOXAZEPINONES AS ION CHANNEL MODULATORS | GILEAD SCIENCES INC (US) | 2020-10-21 | — | — | EP | disclosed |
| EP-1334968-A1 | PROCESS FOR PRODUCING SUBSTITUTED ANILINE COMPOUND | Ihara Chemical Industry Co., Ltd. (JP) | 2003-08-13 | — | — | EP | disclosed |
| WO-2003033475-A1 | PROCESS FOR THE PREPARATION OF 1-(PYRIMIDIN-2-YL)PROPAN-2-ONES | LONZA LTD. (CH) | 2003-04-24 | — | — | WO | disclosed |
| WO-2003033475-A1 | PROCESS FOR THE PREPARATION OF 1-(PYRIMIDIN-2-YL)PROPAN-2-ONES | LONZA LTD. (CH) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034251-A1 | Process for production of substituted aniline compound | NAT1, CBR3, AADAC | LMNA 3459/4885HTT 2412/4885ALDH1A1 189/4885 |
| US-20040242877-A1 | Process for the preparation of 1-(pyrimidin-2-yl) Propan-2-ones | DHPS, PDK2, PDHA2 | LMNA 944/4885HTT 3957/4885ALDH1A1 38/4885 |
| US-20060281765-A1 | Process for producing substituted aniline compound | CBR3, AADAC, NAT1 | LMNA 3401/4885HTT 1962/4885ALDH1A1 207/4885 |
| US-20070213533-A1 | Process for producing substituted aniline compound | AADAC, NAT1, CBR3 | LMNA 2916/4885HTT 1933/4885ALDH1A1 212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.