Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.31 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | GGT1 | P19440 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8722690 | 0.89 | HTT (0.43) | HTTTSHRALDH1A1MEN1LMNA | |
| SCHEMBL8445339 | 0.80 | BACE1 (0.40) | HTTTSHRHIF1AALDH1A1MEN1 | |
| SCHEMBL8309772 | 0.78 | ELANE (0.34) | HTTTSHRALDH1A1MEN1KMT2A | |
| SCHEMBL8782703 | 0.74 | GPR84 (0.34) | HIF1AALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL8782282 | 0.72 | ALDH1A1 (0.34) | TSHRHIF1AALDH1A1MEN1LMNA | |
| SCHEMBL8724020 | 0.72 | MAPT (0.41) | TSHRALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL7816561 | 0.71 | FNTA (0.33) | — | |
| SCHEMBL5646001 | 0.71 | MAPT (0.36) | HIF1AALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL12316024 | 0.71 | CHRM5 (0.37) | HTTHIF1AALDH1A1MAPTKDM4E | |
| SCHEMBL5097862 | 0.70 | KDM4E (0.40) | HTTALDH1A1MEN1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320826-B2 | comprises 3-(4-methoxyphenyl)-3-phenyl-6,7,10,11-tetramethoxy-13-ethyl-13-hydroxy-13H-3H-indeno[2,'3,'3,4]naphtho[1,2-b]pyran; for activation via actinic radiation; improved optical density response; ophthalmic lens | PPG INDUSTRIES OHIO, INC. (US) | 2008-01-22 | — | — | US | claimed |
| US-20040191520-A1 | Photochromic articles with reduced temperature dependency and methods for preparation | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-30 | — | — | US | claimed |
| US-7320826-B2 | comprises 3-(4-methoxyphenyl)-3-phenyl-6,7,10,11-tetramethoxy-13-ethyl-13-hydroxy-13H-3H-indeno[2,'3,'3,4]naphtho[1,2-b]pyran; for activation via actinic radiation; improved optical density response; ophthalmic lens | PPG INDUSTRIES OHIO, INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-20040191520-A1 | Photochromic articles with reduced temperature dependency and methods for preparation | TRANSITIONS OPTICAL LIMITED (IE) | 2004-09-30 | — | — | US | disclosed |