Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 4/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL510120 | 0.87 | MAPT (0.46) | MAPTKDM4EPOLBALDH1A1GAA | |
| SCHEMBL29188157 | 0.87 | KDM4E (0.46) | MAPTKDM4EPOLBTHRBALDH1A1 | |
| Hydrochloric Acid SCHEMBL20740117 | 0.85 | MAPT (0.45) | MAPTKDM4EPOLBALDH1A1GAA | |
| SCHEMBL5929442 | 0.84 | THRB (0.41) | MAPTTHRBTHRAAURKAKDR | |
| SCHEMBL510473 | 0.81 | KDM4E (0.50) | MAPTKDM4EPOLBALDH1A1GAA | |
| SCHEMBL508942 | 0.81 | KDM4E (0.50) | MAPTKDM4EPOLBTHRBALDH1A1 | |
| SCHEMBL3001748 | 0.81 | KDM4E (0.41) | MAPTKDM4EALDH1A1GAAKMT2A | |
| SCHEMBL457051 | 0.81 | ALDH1A1 (0.36) | MAPTALDH1A1GAAKMT2AHPGD | |
| SCHEMBL22067766 | 0.79 | MAPT (0.41) | MAPTKDM4EPOLBALDH1A1GAA | |
| SCHEMBL509061 | 0.79 | AKR1B1 (0.44) | MAPTKDM4EPOLBALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190119298-A1 | FUSED 3-PHENYLTETRAMIC ACID DERIVATIVES HAVING HERBICIDAL ACTION | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2019-04-25 | — | — | US | disclosed |
| EP-3442978-A1 | ANELLATED 3-PHENYL TETRAMIC ACID DERIVATIVES HAVING A HERBICIDAL EFFECT | Bayer CropScience AG (DE) | 2019-02-20 | — | — | EP | disclosed |
| US-8507410-B2 | Pyridazinone compound and use thereof | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-08-13 | — | — | US | disclosed |
| US-8470738-B2 | Pyridazinone compound and herbicide containing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-06-25 | — | — | US | disclosed |
| CN-102421759-A | Pyridazinone compounds and use thereof | SUMITOMO CHEMICAL CO | 2012-04-18 | — | — | CN | disclosed |
| US-20120028803-A1 | PYRIDAZINONE COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-02-02 | — | — | US | disclosed |
| EP-2406232-A1 | PYRIDAZINONE COMPOUND AND USE THEREOF | Sumitomo Chemical Company, Limited (JP) | 2012-01-18 | — | — | EP | disclosed |
| EP-2188264-B1 | PYRIDAZINONE COMPOUND AND HERBICIDE CONTAINING THE SAME | SUMITOMO CHEMICAL CO (JP) | 2011-03-23 | — | — | EP | disclosed |
| WO-2010104217-A1 | PYRIDAZINONE COMPOUND AND USE THEREOF | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2010-09-16 | — | — | WO | disclosed |
| US-20100216642-A1 | PYRIDAZINONE COMPOUND AND HERBICIDE CONTAINING THE SAME | SUMITOMO CHEMICAL COMPANY LIMITED (JP) | 2010-08-26 | — | — | US | disclosed |
| WO-2009035150-A2 | 4-PHENYL-5-HYDROXY-3(2H)-PYRIDAZINONE DERIVATIVES AS HERBICIDES | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2009-03-19 | — | — | WO | disclosed |
| US-20070225170-A1 | 2-Halo-6-Alkylphenyl-Substituted Tetramic Acid Derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2007-09-27 | — | — | US | disclosed |
| US-20070129252-A1 | 2-Halo-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2007-06-07 | — | — | US | disclosed |
| US-20070129252-A1 | 2-Halo-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2007-06-07 | — | — | US | disclosed |
| US-20070129252-A1 | 2-Halo-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2007-06-07 | — | — | US | disclosed |
| CN-1874997-A | 2-halo-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives | BAYER CROPSCIENCE AG (DE) | 2006-12-06 | — | — | CN | disclosed |
| EP-1697321-A1 | 2-HALOGEN-6-ALKYL-PHENYL SUBSTITUTED SPIROCYCLIC TETRAMIC ACID DERIVATIVES | Bayer CropScience AG (DE) | 2006-09-06 | — | — | EP | disclosed |
| EP-1682501-A2 | 2-HALOGEN-6-ALKYL-PHENYL SUBSTITUTED TETRAMIC ACID DERIVATIVES | Bayer CropScience Aktiengesellschaft (DE) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005044796-A1 | 2-HALOGEN-6-ALKYL-PHENYL SUBSTITUTED SPIROCYCLIC TETRAMIC ACID DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2005-05-19 | — | — | WO | disclosed |
| WO-2005044791-A2 | 2-HALOGEN-6-ALKYL-PHENYL-SUBSTITUTED TETRAMIC ACID DERIVATIVES | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2005-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028803-A1 | PYRIDAZINONE COMPOUND AND USE THEREOF | C5, C1S, WEE1 | MAPT 4297/4885KDM4E 3295/4885POLB 3763/4885 |
| US-20100216642-A1 | PYRIDAZINONE COMPOUND AND HERBICIDE CONTAINING THE SAME | WEE1, WEE2, CBR3 | MAPT 4247/4885KDM4E 1987/4885POLB 3977/4885 |
| US-20070129252-A1 | 2-Halo-6-alkylphenyl-substituted spirocyclic tetramic acid derivatives | TBCA, CA6, TRIP13 | MAPT 3645/4885KDM4E 4013/4885POLB 3701/4885 |
| US-20190119298-A1 | FUSED 3-PHENYLTETRAMIC ACID DERIVATIVES HAVING HERBICIDAL ACTION | HPD, AGXT, AADAC | MAPT 1574/4885KDM4E 1882/4885POLB 3590/4885 |
| US-20070225170-A1 | 2-Halo-6-Alkylphenyl-Substituted Tetramic Acid Derivatives | DDT, HDHD5, TBCA | MAPT 3620/4885KDM4E 3947/4885POLB 3158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.