Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 3/20 | 0.40 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8195567 | 0.90 | MAOB (0.53) | ALDH1A1TSHRGRM5MAOBPFKFB3 | |
| SCHEMBL30085021 | 0.86 | CYP3A4 (0.58) | FFAR1SMN1; SMN2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL6819669 | 0.86 | FFAR1 (0.43) | FFAR1SMN1; SMN2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL30223759 | 0.86 | MAOB (0.55) | FFAR1ALDH1A1KDM4EL3MBTL1HTT | |
| SCHEMBL3256254 | 0.86 | MAOB (0.44) | FFAR1MAOB | |
| SCHEMBL3054840 | 0.86 | CYP3A4 (0.58) | FFAR1SMN1; SMN2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL8195129 | 0.86 | ACHE (0.50) | SMN1; SMN2ALDH1A1KDM4EHSD17B10ALDH2 | |
| SCHEMBL7398355 | 0.86 | GRM5 (0.50) | FFAR1SMN1; SMN2KDM4EGRM5HTT | |
| SCHEMBL3484237 | 0.86 | MAOB (0.55) | FFAR1ALDH1A1KDM4EL3MBTL1HTT | |
| SCHEMBL11259709 | 0.86 | FFAR1 (0.52) | FFAR1SMN1; SMN2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1762567-B1 | Pyrazole derivatives for treating HIV | PFIZER LTD (GB) | 2012-05-02 | — | — | EP | disclosed |
| US-20120029192-A1 | Pyrazole Derivatives | PFIZER INC | 2012-02-02 | — | — | US | disclosed |
| US-8063044-B2 | Pyrazole derivatives | PFIZER INC. (US) | 2011-11-22 | — | — | US | disclosed |
| US-20090215712-A1 | PYRAZOLE DERIVATIVES | PFIZER INC | 2009-08-27 | — | — | US | disclosed |
| US-7435728-B2 | Pyrazole derivatives | PFIZER INC (US) | 2008-10-14 | — | — | US | disclosed |
| EP-1556359-B1 | PYRAZOLE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS FOR HIV MEDIATED DISEASES | PFIZER LTD (GB) | 2008-06-18 | — | — | EP | disclosed |
| US-7230025-B2 | Pyrazole derivatives | PFIZER, INC. (US) | 2007-06-12 | — | — | US | disclosed |
| EP-1377556-B1 | PYRAZOLE DERIVATIVES FOR TREATING HIV | PFIZER LTD (GB) | 2007-04-04 | — | — | EP | disclosed |
| EP-1762567-A1 | Pyrazole derivatives for treating HIV | Pfizer Limited (GB) | 2007-03-14 | — | — | EP | disclosed |
| US-7109228-B2 | Pyrazole derivatives | AGOURON PHARMACEUTICALS, INC. (US) | 2006-09-19 | — | — | US | disclosed |
| US-20060020012-A1 | Pyrazole derivatives | PFIZER INC | 2006-01-26 | — | — | US | disclosed |
| US-20050054707-A1 | Pyrazole derivatives | PFIZER INC. | 2005-03-10 | — | — | US | disclosed |
| US-20040132793-A1 | Pyrazole derivatives | PFIZER INC. | 2004-07-08 | — | — | US | disclosed |
| US-20040133002-A1 | Pyrazole derivatives | PFIZER, INC. | 2004-07-08 | — | — | US | disclosed |
| US-20040110816-A1 | Pyrazole derivatives | PFIZER, INC. | 2004-06-10 | — | — | US | disclosed |
| US-20030100554-A1 | Pyrazole derivatives | JONES LYN HOWARD (GB) | 2003-05-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215712-A1 | PYRAZOLE DERIVATIVES | RRM2B, REV1, RRM2 | FFAR1 3320/4885SMN1; SMN2 3225/4885ALDH1A1 1080/4885 |
| US-20040132793-A1 | Pyrazole derivatives | POLA1, REV1, POLR2E | FFAR1 2785/4885SMN1; SMN2 3565/4885ALDH1A1 298/4885 |
| US-20050054707-A1 | Pyrazole derivatives | RTF1, PDCD11, RRM2B | FFAR1 3837/4885SMN1; SMN2 3521/4885ALDH1A1 976/4885 |
| US-20040133002-A1 | Pyrazole derivatives | REV1, RRS1, CYP2F1 | FFAR1 3341/4885SMN1; SMN2 3394/4885ALDH1A1 895/4885 |
| US-20060020012-A1 | Pyrazole derivatives | PDCD11, RTF1, REV1 | FFAR1 3915/4885SMN1; SMN2 3577/4885ALDH1A1 997/4885 |
| US-20120029192-A1 | Pyrazole Derivatives | POLRMT, PDCD11, DPYD | FFAR1 4177/4885SMN1; SMN2 3432/4885ALDH1A1 886/4885 |
| US-20040110816-A1 | Pyrazole derivatives | REV1, POLR2E, SARS1 | FFAR1 2765/4885SMN1; SMN2 2813/4885ALDH1A1 467/4885 |
| US-20030100554-A1 | Pyrazole derivatives | REV1, SARS1, CYP2F1 | FFAR1 3280/4885SMN1; SMN2 2943/4885ALDH1A1 385/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.