Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5105397 | 0.92 | ALDH1A1 (0.42) | LMNASMN1; SMN2ALDH1A1GAAMEN1 | |
| SCHEMBL5092882 | 0.90 | POLB (0.49) | LMNASMN1; SMN2ALDH1A1GAAMEN1 | |
| SCHEMBL5099322 | 0.90 | AKR1C3 (0.35) | CYP2C19SMN1; SMN2ALDH1A1GAAMEN1 | |
| SCHEMBL5105628 | 0.90 | ATM (0.47) | LMNASMN1; SMN2ALDH1A1GAAHSD17B10 | |
| SCHEMBL4693518 | 0.87 | CTSK (0.41) | LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4687256 | 0.85 | CTSK (0.38) | CYP2C19ALDH1A1USP2MEN1KMT2A | |
| SCHEMBL5092592 | 0.84 | LMNA (0.36) | LMNASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL5096610 | 0.84 | GAA (0.39) | LMNASMN1; SMN2ALDH1A1USP2GAA | |
| SCHEMBL5092485 | 0.81 | TP53 (0.47) | LMNA | |
| SCHEMBL5105359 | 0.81 | USP2 (0.36) | LMNASMN1; SMN2ALDH1A1USP2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7405209-B2 | e.g. 2-Benzyloxycarbonylamino-4-methyl-pentanoyl)-3-oxo-azepan-4-ylcarbamoyl}carbamic acid benzyl ester; protease inhibitors like cathepsin K; osteoporosis, osteo- and rheumatoid arthritis and periodontal disease; inhibiting excessive cartilage or matrix degradation | SMITHKLINE BEECHAM CORPORATION (US) | 2008-07-29 | — | — | US | disclosed |
| US-20050256104-A1 | substituted 1,1,4-1l6-trioxo[1,2]thiazepan-4-ylamide-derived protease inhibitors which inhibit the likes of cathepsin K; treating osteoporosis, osteo- and rheumatoid arthritis and periodontal disease; inhibiting excessive cartilage or matrix degradation | SMITHKLINE BEECHAM CORPORATION | 2005-11-17 | — | — | US | disclosed |
| EP-1384713-A1 | 4-amino-azepan-3-one derivatives as protease inhibitors | SmithKline Beecham Corporation (US) | 2004-01-28 | — | — | EP | disclosed |
| US-20040002487-A1 | Protease inhibitors | MARQUIS ROBERT WELLS (US) | 2004-01-01 | — | — | US | disclosed |
| US-20030225061-A1 | Protease inhibitors | MARQUIS ROBERT WELLS (US) | 2003-12-04 | — | — | US | disclosed |
| US-20030144175-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-07-31 | — | — | US | disclosed |
| US-20020147188-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2002-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225061-A1 | Protease inhibitors | CTSK, MMP13, CTSZ | CYP2C19 626/4885LMNA 2800/4885SMN1; SMN2 4669/4885 |
| US-20050256104-A1 | substituted 1,1,4-1l6-trioxo[1,2]thiazepan-4-ylamide-derived protease inhibitors which inhibit the likes of cathepsin K; treating osteoporosis, osteo- and rheumatoid arthritis and periodontal disease; inhibiting excessive cartilage or matrix degradation | CTSK, CTSZ, CTSE | CYP2C19 1707/4885LMNA 3527/4885SMN1; SMN2 4769/4885 |
| US-20020147188-A1 | Protease inhibitors | CTSK, MMP13, CTSZ | CYP2C19 626/4885LMNA 2800/4885SMN1; SMN2 4669/4885 |
| US-20040002487-A1 | Protease inhibitors | CTSK, MMP13, CTSZ | CYP2C19 626/4885LMNA 2800/4885SMN1; SMN2 4669/4885 |
| US-20030144175-A1 | Protease inhibitors | CTSK, MMP13, CTSZ | CYP2C19 626/4885LMNA 2800/4885SMN1; SMN2 4669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.