Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | BLM | P54132 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653328 | 0.78 | ADORA2A (0.46) | KDM4EALDH1A1RCE1HPGDSMN1; SMN2 | |
| SCHEMBL6009722 | 0.71 | MBOAT4 (0.38) | KDM4EALDH1A1RCE1HPGDSMN1; SMN2 | |
| SCHEMBL3548828 | 0.67 | ADORA2A (0.68) | KDM4EALDH1A1TDP1ADORA2AADORA1 | |
| SCHEMBL22968393 | 0.66 | MBOAT4 (1.00) | MBOAT4 | |
| SCHEMBL5229531 | 0.65 | ALDH1A1 (0.47) | KDM4EALDH1A1HPGDSMN1; SMN2GAA | |
| SCHEMBL10372114 | 0.65 | NPC1 (0.56) | KDM4EALDH1A1HPGDSMN1; SMN2MBOAT4 | |
| SCHEMBL14373948 | 0.63 | USP2 (0.48) | KDM4EALDH1A1MBOAT4MEN1KMT2A | |
| SCHEMBL14491199 | 0.63 | ALDH1A1 (0.49) | ALDH1A1MBOAT4 | |
| SCHEMBL5225381 | 0.62 | KDM4E (0.52) | KDM4EALDH1A1HPGDSMN1; SMN2MBOAT4 | |
| SCHEMBL30153455 | 0.62 | ADORA2A (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070932-A1 | Triazolo[ 1,5-A] Pyrimidines And Pyrazolo[ 1,5-A] Pyrimidines And Methods Of Making And Using The Same | BIOGEN IDEC MA INC. | 2008-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070932-A1 | Triazolo[ 1,5-A] Pyrimidines And Pyrazolo[ 1,5-A] Pyrimidines And Methods Of Making And Using The Same | ADORA2B, ADORA2A, ADORA1 | KDM4E 2805/4885ALDH1A1 279/4885RCE1 2666/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.