Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | NQO1 | P15559 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | PCSK7 | Q16549 | 1/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5111826 | 0.84 | NOX4 (0.57) | KDM4ENQO1MEN1KMT2AALDH1A1 | |
| SCHEMBL5114480 | 0.82 | MAOA (0.40) | KDM4EMAOBNQO1MEN1KMT2A | |
| SCHEMBL5120928 | 0.82 | MAOA (0.46) | KDM4EMAOBNQO1MEN1KMT2A | |
| SCHEMBL5115329 | 0.82 | MAOB (0.44) | KDM4EMAOBNQO1MEN1KMT2A | |
| SCHEMBL5118497 | 0.81 | ESR2 (0.49) | KDM4EMAOBMEN1KMT2ACYP3A4 | |
| SCHEMBL5114313 | 0.79 | CA12 (0.52) | MAOBNQO1GPR35CA12CA9 | |
| SCHEMBL5111547 | 0.79 | MAOA (0.59) | KDM4EMAOBNQO1MEN1KMT2A | |
| SCHEMBL5112059 | 0.79 | NQO1 (0.55) | MAOBNQO1MEN1KMT2ALMNA | |
| SCHEMBL5125176 | 0.79 | MAOB (0.56) | KDM4EMAOBNQO1MEN1KMT2A | |
| SCHEMBL5111346 | 0.79 | NQO1 (0.57) | KDM4EMAOBNQO1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7384975-B2 | Substituted furochromenes, preparation thereof and their antiinflammatory action | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2008-06-10 | — | — | US | claimed |
| US-20060148889-A1 | Substituted furochromenes, preparation thereof and their antiinflammatory action | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2006-07-06 | — | — | US | claimed |
| EP-1648902-A1 | SUBSTITUTED FUROCHROMENES, PREPARATION THEREOF AND THEIR ANTIINFLAMMATORY ACTION | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2006-04-26 | — | — | EP | claimed |
| WO-2005010007-A1 | SUBSTITUTED FUROCHROMENES, PREPARATION THEREOF AND THEIR ANTIINFLAMMATORY ACTION | PLIVA- ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-02-03 | — | — | WO | claimed |
| EP-3606517-B1 | COUMARIN DERIVATIVE AS ANTI-ASTHMATIC AGENT, PHARMACEUTICAL COMPOSITION THEREOF AND USE | I NOVA MEDICINSKA ISTRAZIVANJA D O O (HR) | 2022-05-25 | — | — | EP | disclosed |
| US-20210113522-A1 | COUMARIN DERIVATIVE AS ANTI-ASTHMATIC AGENT, PHARMACEUTICAL COMPOSITION THEREOF, ITS PREPARATION AND USE | I-NOVA MEDICINSKA ISTRAZIVANJA D.O.O. (HR) | 2021-04-22 | — | — | US | disclosed |
| EP-3277692-B1 | COUMARIN DERIVATIVE AS ANTIVIRAL AGENT, PHARMACEUTICAL COMPOSITION THEREOF, ITS PREPARATION AND USE | I NOVA MEDICINSKA ISTRAZIVANJA D O O (HR) | 2019-09-11 | — | — | EP | disclosed |
| US-10266545-B2 | Coumarin derivative as antiviral agent, pharmaceutical composition thereof, its preparation and use | I-NOVA MEDICINSKA ISTRAZIVANJA D.O.O. (HR) | 2019-04-23 | — | — | US | disclosed |
| US-20180072752-A1 | COUMARIN DERIVATIVE AS ANTIVIRAL AGENT, PHARMACEUTICAL COMPOSITION THEREOF, ITS PREPARATION AND USE | I-NOVA MEDICINSKA ISTRAZIVANJA D.O.O. (HR) | 2018-03-15 | — | — | US | disclosed |
| US-20180072752-A1 | COUMARIN DERIVATIVE AS ANTIVIRAL AGENT, PHARMACEUTICAL COMPOSITION THEREOF, ITS PREPARATION AND USE | I-NOVA MEDICINSKA ISTRAZIVANJA D.O.O. (HR) | 2018-03-15 | — | — | US | disclosed |
| US-7384975-B2 | Substituted furochromenes, preparation thereof and their antiinflammatory action | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2008-06-10 | — | — | US | disclosed |
| US-7384975-B2 | Substituted furochromenes, preparation thereof and their antiinflammatory action | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2008-06-10 | — | — | US | disclosed |
| US-7384975-B2 | Substituted furochromenes, preparation thereof and their antiinflammatory action | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (HR) | 2008-06-10 | — | — | US | disclosed |
| US-20060148889-A1 | Substituted furochromenes, preparation thereof and their antiinflammatory action | PLIVA-ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2006-07-06 | — | — | US | disclosed |
| EP-1648902-A1 | SUBSTITUTED FUROCHROMENES, PREPARATION THEREOF AND THEIR ANTIINFLAMMATORY ACTION | PLIVA-ISTRAZIVACKI INSTITUT d.o.o. (HR) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005010007-A1 | SUBSTITUTED FUROCHROMENES, PREPARATION THEREOF AND THEIR ANTIINFLAMMATORY ACTION | PLIVA- ISTRAZIVACKI INSTITUT D.O.O. (HR) | 2005-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148889-A1 | Substituted furochromenes, preparation thereof and their antiinflammatory action | CYP11B2, CYP11B1, LTC4S | KDM4E 3765/4885MAOB 322/4885NQO1 60/4885 |
| US-20180072752-A1 | COUMARIN DERIVATIVE AS ANTIVIRAL AGENT, PHARMACEUTICAL COMPOSITION THEREOF, ITS PREPARATION AND USE | CYP3A7, MAVS, SARS1 | KDM4E 3007/4885MAOB 3312/4885NQO1 609/4885 |
| US-10266545-B2 | Coumarin derivative as antiviral agent, pharmaceutical composition thereof, its preparation and use | CYP3A7, MAVS, SARS1 | KDM4E 3007/4885MAOB 3312/4885NQO1 609/4885 |
| US-20210113522-A1 | COUMARIN DERIVATIVE AS ANTI-ASTHMATIC AGENT, PHARMACEUTICAL COMPOSITION THEREOF, ITS PREPARATION AND USE | CYP8B1, CYP4B1, CYP3A7 | KDM4E 1836/4885MAOB 3043/4885NQO1 824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.