Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5653075 | 0.94 | ALDH1A1 (0.39) | GSK3AGSK3BALDH1A1ELANEKMT2A | |
| SCHEMBL30028689 | 0.85 | MEN1 (0.43) | GSK3AGSK3BALDH1A1KMT2AMEN1 | |
| SCHEMBL5114769 | 0.84 | MEN1 (0.40) | GSK3AGSK3BALDH1A1ELANEKMT2A | |
| SCHEMBL3645840 | 0.83 | GSK3A (0.45) | GSK3AGSK3BALDH1A1ELANEKMT2A | |
| SCHEMBL8912197 | 0.82 | KMT2A (0.45) | ALDH1A1KMT2AMEN1MAPTPOLB | |
| SCHEMBL8912207 | 0.81 | MEN1 (0.38) | GSK3AGSK3BALDH1A1KMT2AMEN1 | |
| SCHEMBL3689858 | 0.79 | BRD4 (0.41) | ALDH1A1KMT2AMEN1KDM4EGAA | |
| Ethyl Bromo Acetate SCHEMBL30029142 | 0.79 | ALDH1A1 (0.47) | ALDH1A1KMT2AMEN1ABL1RIN1 | |
| SCHEMBL915985 | 0.78 | ALDH1A1 (0.50) | ALDH1A1KMT2AMEN1POLBHPGD | |
| Hydrochloric Acid SCHEMBL3693041 | 0.77 | BRD4 (0.39) | ALDH1A1KMT2AMEN1KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080275241-A1 | Polymorphic Forms of Dolasetron Base and Processes of Preparing Dolasetron Base, Its Polymorphic Forms and Salt Thereof | USV LIMITED (IN) | 2008-11-06 | — | — | US | disclosed |
| US-20080275241-A1 | Polymorphic Forms of Dolasetron Base and Processes of Preparing Dolasetron Base, Its Polymorphic Forms and Salt Thereof | USV LIMITED (IN) | 2008-11-06 | — | — | US | disclosed |
| US-20070299260-A1 | Method for Preparing Hexahydro-8-Hydroxy-2, 6-Methano-2H-Chinolizin-3 (4H) -One Esters | CILAG LTD. (CH) | 2007-12-27 | — | — | US | disclosed |
| EP-1819705-A1 | METHOD FOR PREPARING HEXAHYDRO-8-HYDROXY-2,6-METHANO-2H-CHINOLIZIN-3(4H)-ONE ESTERS | Cilag Ltd. (CH) | 2007-08-22 | — | — | EP | disclosed |
| WO-2007072507-A2 | POLYMORPHIC FORMS OF DOLASETRON BASE AND PROCESSES OF PREPARING DOLASETRON BASE, ITS POLYMORPHIC FORMS AND SALT THEREOF | USV LIMITED (IN) | 2007-06-28 | — | — | WO | disclosed |
| WO-2007072506-A2 | POLYMORPHIC FORMS OF DOLASETRON MESYLATE AND PROCESSES THEREOF | USV LIMITED (IN) | 2007-06-28 | — | — | WO | disclosed |
| WO-2006056081-A1 | METHOD FOR PREPARING HEXAHYDRO-8-HYDROXY-2,6-METHANO-2H-CHINOLIZIN-3(4H)-ONE ESTERS | CILAG LTD. (CH) | 2006-06-01 | — | — | WO | disclosed |
| US-5910501-A | Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolozin-3(4H)-one and related compounds for treating cognitive disorders | MERRELL PHARMACEUTICALS INC. (US) | 1999-06-08 | — | — | US | disclosed |
| EP-0329932-B1 | Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments | MERRELL DOW PHARMA (US) | 1995-10-18 | — | — | EP | disclosed |
| EP-0266730-B1 | Esters of hexadydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds | MERRELL DOW PHARMA (US) | 1994-08-10 | — | — | EP | disclosed |
| EP-0494002-A2 | Use of certain esters of hexahydro-8-hydroxy-2, 6-methano-2H-quinolizin-3(4H)-one and related compounds for the preparation of medicaments for treating cognitive disorders | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-08 | — | — | EP | disclosed |
| EP-0492020-A1 | Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-01 | — | — | EP | disclosed |
| US-5011846-A | Medicament compositions derived from quinolizine and quinolizinone and methods of use thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-04-30 | — | — | US | disclosed |
| US-4906755-A | Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-06 | — | — | US | disclosed |
| EP-0330824-A1 | Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments for the treatment of cardiac arrhythmias | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-09-06 | — | — | EP | disclosed |
| EP-0329932-A2 | Use of quinolizine and quinolizinone derivatives in the manufacture of medicaments | MERRELL PHARMACEUTICALS INC. (US) | 1989-08-30 | — | — | EP | disclosed |
| EP-0266730-A1 | Esters of hexadydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-05-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080275241-A1 | Polymorphic Forms of Dolasetron Base and Processes of Preparing Dolasetron Base, Its Polymorphic Forms and Salt Thereof | CYP4A11, CYP3A43, VKORC1 | GSK3A 1509/4885GSK3B 1506/4885ALDH1A1 3375/4885 |
| US-20070299260-A1 | Method for Preparing Hexahydro-8-Hydroxy-2, 6-Methano-2H-Chinolizin-3 (4H) -One Esters | CYP4Z1, HDHD5, HCAR2 | GSK3A 3758/4885GSK3B 4142/4885ALDH1A1 541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.