Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GRM5 | P41594 | 7/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 5/20 | 0.45 |
| ▸ | BCR | P11274 | 5/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.44 |
| ▸ | ATXN2 | Q99700 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5129768 | 0.89 | GRM5 (0.54) | GRM5HSD11B1ENPP2ATXN2 | |
| SCHEMBL5124023 | 0.84 | SMN1; SMN2 (0.58) | GRM5HSD11B1 | |
| SCHEMBL5120360 | 0.83 | HPGD (0.48) | MAPTGRM5LMNAENPP2ATXN2 | |
| SCHEMBL5124060 | 0.82 | ENPP2 (0.48) | GRM5HSD11B1LMNAHTR1AENPP2 | |
| SCHEMBL5125577 | 0.81 | PKM (0.47) | GRM5LMNAENPP2ATXN2 | |
| SCHEMBL5115603 | 0.81 | MGLL (0.51) | MAPTGRM5LMNAENPP2ATXN2 | |
| SCHEMBL5129080 | 0.81 | MGLL (0.53) | MAPTGRM5LMNAENPP2ATXN2 | |
| SCHEMBL5130061 | 0.81 | HSD11B1 (0.53) | MAPTGRM5HSD11B1LMNAENPP2 | |
| SCHEMBL5129000 | 0.80 | GRM5 (0.52) | MAPTGRM5LMNAENPP2ATXN2 | |
| SCHEMBL5122942 | 0.80 | PKLR (0.49) | MAPTGRM5LMNAENPP2ATXN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269250-A1 | Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists | NOVARTIS AG (CH) | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269250-A1 | Pyrrolidine and Piperidine Acetylene Derivatives for Use as Mglur5 Antagonists | GRM5, GRIK5, GRM1 | MAPT 1486/4885GRM5 1/4885HSD11B1 3961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.