SCHEMBL5124397

SCHEMBL5124397

O=C(Nc1ccc2c(c1)OCO2)Oc1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 1.00
MAPT P10636 6/20 1.00
NPC1 O15118 12/20 0.66
RAB9A P51151 12/20 0.66
SMN1; SMN2 Q16637 5/20 0.66
TP53 P04637 1/20 0.66
TSHR P16473 1/20 0.66
ATM Q13315 1/20 0.66
HTT P42858 2/20 0.62
KMT2A Q03164 3/20 0.60
MEN1 O00255 2/20 0.60
POLB P06746 2/20 0.60
CYP1A2 P05177 2/20 0.60
CYP3A4 P08684 2/20 0.60
CYP2D6 P10635 2/20 0.60
CYP2C9 P11712 2/20 0.60
CYP2C19 P33261 2/20 0.60
CASP3 P42574 1/20 0.57
SENP8 Q96LD8 1/20 0.57
SENP7 Q9BQF6 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4456132 0.91 MAPT (0.84) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL3578866 0.80 NPC1 (0.73) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL29739659 0.80 ALDH1A1 (0.66) ALDH1A1MAPTNPC1RAB9ATP53
SCHEMBL29177443 0.80 ALDH1A1 (0.66) ALDH1A1MAPTNPC1RAB9ATP53
SCHEMBL2092454 0.79 NPC1 (0.68) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL12010919 0.79 RAB9A (0.84) MAPTNPC1RAB9ASMN1; SMN2TP53
SCHEMBL4647917 0.78 NPC1 (0.77) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL29947811 0.78 ALDH1A1 (0.64) ALDH1A1MAPTSMN1; SMN2TP53HTT
SCHEMBL6295679 0.78 NPC1 (1.00) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL8063648 0.78 ALDH1A1 (0.82) ALDH1A1MAPTRAB9ASMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4662206-A1 GSPT1 DEGRADER COMPOUNDS Captor Therapeutics S.A. (PL) 2025-12-17 EP disclosed
WO-2024167423-A1 GSPT1 DEGRADER COMPOUNDS CAPTOR THERAPEUTICS S.A. (PL) 2024-08-15 WO disclosed
WO-2024165577-A1 GSPT1 DEGRADER COMPOUNDS CAPTOR THERAPEUTICS S.A. (PL) 2024-08-15 WO disclosed
US-20240216355-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS MONTE ROSA THERAPEUTICS AG (CH) 2024-07-04 US disclosed
EP-4313047-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS Monte Rosa Therapeutics, Inc. (US) 2024-02-07 EP disclosed
WO-2022200857-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS MONTE ROSA THERAPEUTICS AG (CH) 2022-09-29 WO disclosed
EP-4041231-A1 ISOINDOLINONE COMPOUNDS Monte Rosa Therapeutics AG (CH) 2022-08-17 EP disclosed
US-20220242846-A1 ISOINDOLINONE COMPOUNDS MONTE ROSA THERAPEUTICS AG (CH) 2022-08-04 US disclosed
WO-2021069705-A1 ISOINDOLINONE COMPOUNDS MONTE ROSA THERAPEUTICS (CH) 2021-04-15 WO disclosed
WO-2021069705-A1 ISOINDOLINONE COMPOUNDS MONTE ROSA THERAPEUTICS (CH) 2021-04-15 WO disclosed
EP-3224252-B1 SUBSTITUTED OXAZOLE- AND THIAZOLE-BASED CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS II MEDIFRON DBT INC (KR) 2019-01-09 EP disclosed
US-9771359-B1 Substituted oxazole- and thiazole-based carboxamide and urea derivatives as vanilloid receptor ligands II MEDIFRON DBT INC. (KR) 2017-09-26 US disclosed
US-20170253586-A1 Substituted Oxazole- and Thiazole-Based Carboxamide and Urea Derivatives as Vanilloid Receptor Ligands II MEDIFRON DBT INC. (KR) 2017-09-07 US disclosed
WO-2014019044-A1 HYDRAZIDE-N-ACYLHYDRAZONE COMPOUNDS, METHOD FOR PRODUCING HYDRAZIDE-N-ACYLHYDRAZONE COMPOUNDS, USE OF INTERMEDIATE COMPOUNDS FOR PRODUCING HYDRAZIDE-N-ACYLHYDRAZONES FOF THE TREATMENT OF LEISHMANIASIS AND CHAGAS DISEASE, AND THUS OBTAINED PHARMACEUTICAL COMPOSITIONS UNIVERSIDADE FEDERAL DO RIO DE JANEIRO (BR) 2014-02-06 WO disclosed
US-20080045546-A1 Tetradydro-Naphthalene And Urea Derivatives BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-02-21 US disclosed
US-20080045546-A1 Tetradydro-Naphthalene And Urea Derivatives BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-02-21 US disclosed
US-20080045546-A1 Tetradydro-Naphthalene And Urea Derivatives BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) 2008-02-21 US disclosed
EP-1678123-A1 TETRAHYDRO-NAPHTHALENE AND UREA DERIVATIVES Bayer HealthCare AG (DE) 2006-07-12 EP disclosed
WO-2005040100-A1 TETRAHYDRO-NAPHTHALENE AND UREA DERIVATIVES BAYER HEALTHCARE AG (DE) 2005-05-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240216355-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS UPF1, NSUN2, RTF2 ALDH1A1 4150/4885MAPT 4671/4885NPC1 330/4885
US-20170253586-A1 Substituted Oxazole- and Thiazole-Based Carboxamide and Urea Derivatives as Vanilloid Receptor Ligands II TRPV1, TRPV2, GPR17 ALDH1A1 1621/4885MAPT 1740/4885NPC1 1959/4885
US-20220242846-A1 ISOINDOLINONE COMPOUNDS AOC2, AOC3, INF2 ALDH1A1 1331/4885MAPT 4852/4885NPC1 356/4885
US-20080045546-A1 Tetradydro-Naphthalene And Urea Derivatives NMUR1, GPR17, NMUR2 ALDH1A1 477/4885MAPT 949/4885NPC1 880/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.