Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | PPM1D | O15297 | 1/20 | 0.34 |
| ▸ | PPM1B | O75688 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.34 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.31 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.31 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.31 |
| ▸ | TLR4 | O00206 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4776880 | 0.86 | FKBP1A (0.39) | FKBP1AMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL2697327 | 0.85 | PPM1D (0.33) | PPM1DHSD17B10 | |
| SCHEMBL2699274 | 0.85 | PPM1D (0.33) | PPM1DHSD17B10 | |
| SCHEMBL5133262 | 0.83 | RAB9A (0.37) | FKBP1AMAPTPPM1DPPM1BPTPN1 | |
| SCHEMBL18548904 | 0.81 | PPM1D (0.32) | PPM1D | |
| SCHEMBL28580288 | 0.77 | PPM1D (0.34) | PPM1D | |
| SCHEMBL924412 | 0.77 | PPM1D (0.34) | PPM1D | |
| SCHEMBL922722 | 0.77 | PPM1D (0.34) | PPM1D | |
| SCHEMBL23008569 | 0.77 | P2RX3 (0.37) | FKBP1AMAPTPPM1DALDH1A1MEN1 | |
| SCHEMBL2197772 | 0.77 | P2RX3 (0.37) | FKBP1AMAPTPPM1DALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893599-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006134378-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |