Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PPM1D | O15297 | 1/20 | 0.35 |
| ▸ | ACE | P12821 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PPM1B | O75688 | 1/20 | 0.32 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.32 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25273987 | 0.87 | HSD17B10 (0.39) | PPM1DCYP2C19HSD17B10ALDH1A1RECQL | |
| SCHEMBL25273988 | 0.87 | HSD17B10 (0.39) | PPM1DCYP2C19HSD17B10ALDH1A1RECQL | |
| SCHEMBL2697327 | 0.86 | PPM1D (0.33) | PPM1DLMNACYP2C19HSD17B10 | |
| SCHEMBL2699274 | 0.86 | PPM1D (0.33) | PPM1DLMNACYP2C19HSD17B10 | |
| SCHEMBL5133260 | 0.83 | FKBP1A (0.41) | PPM1DHSD17B10MAPTPPM1BPTPN1 | |
| SCHEMBL4776880 | 0.83 | FKBP1A (0.39) | CYP2C19HSD17B10MAPTFKBP1AALDH1A1 | |
| SCHEMBL14494473 | 0.80 | MMP2 (0.36) | PPM1DMAPTFKBP1AALDH1A1GAA | |
| SCHEMBL22980252 | 0.79 | GBA2 (0.36) | PPM1DLMNA | |
| SCHEMBL9384319 | 0.77 | CYP19A1 (0.33) | PPM1D | |
| SCHEMBL30104016 | 0.76 | TSHR (0.37) | PPM1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893599-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | AstraZeneca AB (SE) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006134378-A1 | COMPOUNDS FOR THE TREATMENT OF MULTI-DRUG RESISTANT BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2006-12-21 | — | — | WO | disclosed |