Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.52 |
| ▸ | NPC1 | O15118 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.52 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.52 |
| ▸ | RELA | Q04206 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HAVCR2 | Q8TDQ0 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL513092 | 0.85 | NPC1 (0.46) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL513589 | 0.84 | NPC1 (0.47) | RAB9ANPC1SMN1; SMN2TP53NFKB1 | |
| SCHEMBL513254 | 0.84 | TP53 (0.45) | RAB9ANPC1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL513204 | 0.83 | HDAC6 (0.44) | RAB9ANPC1SMN1; SMN2TP53NFKB1 | |
| SCHEMBL512771 | 0.82 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2TDP1ALDH1A1 | |
| SCHEMBL513221 | 0.78 | CHRNB2 (0.49) | RAB9ANPC1SMN1; SMN2TP53NFKB1 | |
| SCHEMBL513425 | 0.77 | NPC1 (0.45) | RAB9ANPC1SMN1; SMN2TP53NFKB1 | |
| SCHEMBL512093 | 0.75 | NPC1 (0.41) | RAB9ANPC1SMN1; SMN2TP53NFKB1 | |
| SCHEMBL512821 | 0.74 | CA2 (0.41) | RAB9ANPC1TDP1ALDH1A1POLB | |
| SCHEMBL513461 | 0.74 | CCR1 (0.37) | RAB9ANPC1SMN1; SMN2TP53TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | RAB9A 2058/4885NPC1 4017/4885SMN1; SMN2 411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.