Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | CASP3 | P42574 | 5/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 5/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 4/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL514450 | 1.00 | NR1H4 (0.44) | NR1H4CASP3SENP7SENP6SENP8 | |
| SCHEMBL513463 | 1.00 | NR1H4 (0.44) | NR1H4CASP3SENP7SENP6SENP8 | |
| SCHEMBL513422 | 0.93 | NR1H4 (0.45) | NR1H4CASP3SENP7SENP6SENP8 | |
| SCHEMBL513442 | 0.90 | NR1H4 (0.47) | NR1H4CASP3SENP7SENP6SENP8 | |
| SCHEMBL513871 | 0.88 | CASP3 (0.42) | NR1H4CASP3SENP7SENP6SENP8 | |
| SCHEMBL513870 | 0.88 | CASP3 (0.42) | NR1H4CASP3SENP7SENP6SENP8 | |
| SCHEMBL14562709 | 0.70 | NR1H4 (0.57) | NR1H4CASP3SENP7SENP6SENP8 | |
| SCHEMBL23830703 | 0.69 | PNMT (0.43) | MAOBPRCPHTR2C | |
| SCHEMBL23850346 | 0.69 | PNMT (0.43) | MAOBPRCPHTR2C | |
| SCHEMBL512905 | 0.67 | RAB9A (0.51) | NR1H4CASP3SENP7SENP6SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477981-A1 | HETEROCYCLIC MGLU5 ANTAGONISTS | Recordati Ireland Limited (IE) | 2012-07-25 | — | — | EP | disclosed |
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | NR1H4 503/4885CASP3 4165/4885SENP7 3588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.