Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.51 |
| ▸ | RAB9A | P51151 | 12/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 11/20 | 0.51 |
| ▸ | HPGD | P15428 | 10/20 | 0.51 |
| ▸ | NPC1 | O15118 | 9/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 3/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10475798 | 0.78 | RAB9A (0.47) | KDM4EALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL512888 | 0.76 | HDAC1 (0.41) | KDM4EALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL512779 | 0.76 | MAOA (0.44) | KDM4EALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL13762461 | 0.73 | KDM4E (0.70) | KDM4EALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL28975849 | 0.72 | KDM4E (0.62) | KDM4EALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL512846 | 0.71 | KDM4E (0.46) | KDM4EALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL513704 | 0.71 | RAB9A (0.40) | KDM4EALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL22471879 | 0.67 | ATAD2 (0.61) | KDM4EALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL7058937 | 0.67 | KDM4E (0.67) | KDM4EALDH1A1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL30310194 | 0.66 | ALDH1A1 (0.53) | KDM4EALDH1A1RAB9ASMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | RECORDATI IRELAND LIMITED (IE) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028931-A1 | HETEROCYCLIC M-GLU5 ANTAGONISTS | OPRM1, GRM5, OPRD1 | KDM4E 3490/4885ALDH1A1 2610/4885RAB9A 2058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.