Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 6/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.35 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL513972 | 1.00 | HSD11B1 (0.36) | HSD11B1PGRTRPA1CCR1OPRM1 | |
| SCHEMBL2508530 | 0.86 | OPRL1 (0.42) | HSD11B1PGRTRPA1OPRM1OPRL1 | |
| SCHEMBL2030849 | 0.84 | OPRL1 (0.38) | HSD11B1PGRTRPA1OPRM1OPRL1 | |
| SCHEMBL1352509 | 0.84 | OPRL1 (0.39) | HSD11B1PGRTRPA1CCR1OPRM1 | |
| SCHEMBL1351916 | 0.84 | PGR (0.37) | HSD11B1PGRTRPA1OPRM1OPRL1 | |
| SCHEMBL2051577 | 0.76 | F11 (0.39) | — | |
| SCHEMBL14915911 | 0.74 | — | — | |
| SCHEMBL514505 | 0.73 | CES2 (0.34) | OPRM1OPRL1 | |
| SCHEMBL1900125 | 0.70 | CTSL (0.32) | OPRM1OPRL1 | |
| SCHEMBL14876759 | 0.70 | PGR (0.40) | PGRCCR1OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028918-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF MAKING SAME | GLAXO WELLCOME MANUFACTURING PTE LTD. (SG) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028918-A1 | PHARMACEUTICAL COMPOSITIONS AND METHODS OF MAKING SAME | PIK3CA, G6PC1, PIK3C2B | HSD11B1 778/4885PGR 1078/4885TRPA1 4858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.