Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FTO | Q9C0B1 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.30 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.30 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.30 |
| ▸ | CDK1 | P06493 | 1/20 | 0.30 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.30 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16533076 | 0.80 | ALDH1A1 (0.47) | FTOALDH1A1JAK3NPC1RAB9A | |
| SCHEMBL19954102 | 0.77 | FTO (0.40) | FTOALDH1A1JAK3NPC1RAB9A | |
| SCHEMBL7535989 | 0.75 | FTO (0.45) | FTOALDH1A1JAK3NPC1RAB9A | |
| SCHEMBL15657999 | 0.74 | FTO (0.42) | FTOALDH1A1JAK3PLA2G4ANPC1 | |
| SCHEMBL16532962 | 0.70 | FTO (0.47) | FTOALDH1A1JAK3NPC1RAB9A | |
| SCHEMBL21226224 | 0.70 | KMT2A (0.38) | ALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7994155 | 0.69 | ALDH1A1 (0.52) | ALDH1A1PLA2G4ASMN1; SMN2TBXAS1CCNB2 | |
| SCHEMBL5141219 | 0.69 | ALDH1A1 (0.40) | FTOALDH1A1PLA2G4ASMN1; SMN2FBP1 | |
| SCHEMBL20902790 | 0.69 | FTO (0.37) | FTOJAK3NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13369212 | 0.68 | ALDH1A1 (0.42) | FTOALDH1A1PLA2G4AFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966202-A1 | HETEROARYL SUBSTITUTED PYRROLOÝ2,3-B¨PYRIDINES AND PYRROLOÝ2,3-B¨PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070514-A1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-B]PYRIDINES AND PYRROLO[2,3-B]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2007-06-21 | — | — | WO | disclosed |