Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PLA2G4A | P47712 | 3/20 | 0.34 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.31 |
| ▸ | FBP1 | P09467 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13369212 | 0.87 | ALDH1A1 (0.42) | ALDH1A1PLA2G4ACES1FTOFBP1 | |
| SCHEMBL13369309 | 0.80 | ALDH1A1 (0.52) | ALDH1A1CYP2C19SMN1; SMN2FTO | |
| SCHEMBL7535989 | 0.71 | FTO (0.45) | ALDH1A1SMN1; SMN2FTO | |
| SCHEMBL7192569 | 0.71 | ALDH1A1 (0.42) | ALDH1A1FTO | |
| SCHEMBL5141220 | 0.69 | FTO (0.41) | ALDH1A1PLA2G4ACCNB2CCNE2CDK1 | |
| Bromide SCHEMBL6329679 | 0.68 | PLA2G4A (0.56) | ALDH1A1PLA2G4ACCNB2CCNE2CDK1 | |
| SCHEMBL16533076 | 0.66 | ALDH1A1 (0.47) | ALDH1A1CYP2C19SMN1; SMN2FTO | |
| SCHEMBL19954102 | 0.65 | FTO (0.40) | ALDH1A1FTO | |
| SCHEMBL27563650 | 0.65 | ALDH1A1 (0.50) | ALDH1A1PLA2G4AADORA2ACES1SMN1; SMN2 | |
| SCHEMBL2042556 | 0.64 | ALDH1A1 (0.49) | ALDH1A1PLA2G4ACES1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966202-A1 | HETEROARYL SUBSTITUTED PYRROLOÝ2,3-B¨PYRIDINES AND PYRROLOÝ2,3-B¨PYRIMIDINES AS JANUS KINASE INHIBITORS | Incyte Corporation (US) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007070514-A1 | HETEROARYL SUBSTITUTED PYRROLO[2,3-B]PYRIDINES AND PYRROLO[2,3-B]PYRIMIDINES AS JANUS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2007-06-21 | — | — | WO | disclosed |