Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5145778 | 0.88 | HSP90AB1 (0.48) | HSP90AB1KMT2AMEN1TNFNOD2 | |
| SCHEMBL5145806 | 0.86 | LMNA (0.51) | HSP90AB1KMT2AMEN1NOD1KDM4E | |
| SCHEMBL5145876 | 0.86 | PDE4B (0.42) | HSP90AB1KMT2ATSHRMEN1RAB9A | |
| SCHEMBL5142466 | 0.85 | ALDH1A1 (0.48) | KMT2ATSHRMEN1DRD2KCNH2 | |
| SCHEMBL5144627 | 0.83 | ABCB1 (0.53) | KMT2AABCB1TNFNOD2NOD1 | |
| SCHEMBL5142455 | 0.80 | CHRNB2 (0.52) | TSHRDRD2KCNH2KDM4ELMNA | |
| SCHEMBL5141439 | 0.80 | SIGMAR1 (0.49) | KMT2AMEN1RAB9ADRD2KDM4E | |
| SCHEMBL5145737 | 0.79 | ALDH1A1 (0.46) | KMT2ATSHRMEN1KDM4EUSP2 | |
| SCHEMBL5141466 | 0.77 | MAPT (0.53) | KMT2ATSHRMAPK1MEN1RAB9A | |
| SCHEMBL6370338 | 0.75 | PNMT (0.40) | DRD2KCNH2LMNAPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |