Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.41 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PNMT | P11086 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CLPP | Q16740 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5144592 | 0.88 | HSP90AB1 (0.49) | HSP90AB1LMNAKDM4EALDH1A1TNF | |
| SCHEMBL5145806 | 0.88 | LMNA (0.51) | HSP90AB1LMNAKDM4EALDH1A1MAPT | |
| SCHEMBL5145876 | 0.87 | PDE4B (0.42) | HSP90AB1LMNALSSALDH1A1MAPT | |
| SCHEMBL5141439 | 0.86 | SIGMAR1 (0.49) | LMNAKDM4EALDH1A1MAPTSIGMAR1 | |
| SCHEMBL5144627 | 0.84 | ABCB1 (0.53) | ALDH1A1TNFNOD2NOD1SIGMAR1 | |
| SCHEMBL5141466 | 0.81 | MAPT (0.53) | LMNAKDM4EALDH1A1MAPTSIGMAR1 | |
| SCHEMBL5142455 | 0.81 | CHRNB2 (0.52) | LMNAKDM4EALDH1A1CLPP | |
| SCHEMBL5142466 | 0.78 | ALDH1A1 (0.48) | KDM4EALDH1A1MEN1KMT2ACLPP | |
| SCHEMBL4881580 | 0.78 | HSD17B10 (0.35) | HSP90AB1LMNALSSMAPT | |
| SCHEMBL6370338 | 0.76 | PNMT (0.40) | LMNAPNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7297700-B2 | Bicycloheteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS, INC. (US) | 2007-11-20 | — | — | US | claimed |