Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Trolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trolamine SCHEMBL11132413 | 1.00 | MAPT (0.44) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL6711907 | 0.96 | MAPT (0.41) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL5051612 | 0.96 | TSHR (0.42) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL11071448 | 0.96 | MAPT (0.41) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL27733888 | 0.96 | MAPT (0.41) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL15845959 | 0.95 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL1146 | 0.95 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL4748243 | 0.95 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL434089 | 0.95 | MAPT (0.47) | MAPTKDM4ESMN1; SMN2ALOX15HPGD | |
| Trolamine SCHEMBL8576219 | 0.92 | MAPT (0.39) | MAPTKDM4ESMN1; SMN2ALOX15HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 260 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120054508-A | CoAs (CoAs)3Catalyst, preparation method and application thereof | 陕西师范大学 | 2025-05-30 | — | — | CN | claimed |
| CN-119912747-A | Polypropylene composite material with high heat conduction and good appearance and preparation method thereof | 广东圆融新材料有限公司 | 2025-05-02 | — | — | CN | claimed |
| CN-119797921-A | Ultrahigh-strength carbon material and preparation method thereof | 哈尔滨工业大学 | 2025-04-11 | — | — | CN | claimed |
| CN-117534535-B | Strong conjugated organic small molecular material and preparation method and application thereof | 齐鲁工业大学(山东省科学院) | 2025-03-14 | — | — | CN | claimed |
| CN-119405604-A | SHAP short peptide-loaded silicone liposome nano-particle, and preparation method and application thereof | 天津医科大学 | 2025-02-11 | — | — | CN | claimed |
| CN-119345388-A | Nanoparticle preparation and preparation method and application thereof | 上海市第六人民医院 | 2025-01-24 | — | — | CN | claimed |
| CN-119346017-A | Polyurethane coated diethyl aminoethyl hexanoate slow-release microsphere, and preparation method and application thereof | 中国水稻研究所 | 2025-01-24 | — | — | CN | claimed |
| CN-119139444-A | Traditional Chinese medicine composition for treating chilblain and preparation method thereof | 常州市武进人民医院(常州市第八人民医院) | 2024-12-17 | — | — | CN | claimed |
| CN-119140145-A | S, na and B co-doped cyano-rich graphite phase carbon nitride photo-responsive catalyst and preparation method and application thereof | 陕西华添氢能科技有限公司 | 2024-12-17 | — | — | CN | claimed |
| CN-119019781-A | EVA injection molding supercritical physical foaming material and preparation method thereof | 晋江市石达塑胶精细有限公司 | 2024-11-26 | — | — | CN | claimed |
| CN-115990119-A | Anti-aging skin care stock solution and preparation method and application thereof | 三蚁科技(广州)有限公司 | 2023-04-21 | — | — | CN | claimed |
| CN-115651103-A | Method for preparing low-aldehyde content polyvinyl butyral resin | 万华化学集团股份有限公司 | 2023-01-31 | — | — | CN | claimed |
| CN-114946866-A | Metronidazole polyurethane microcapsule suspending agent and preparation method thereof | 中国农业科学院植物保护研究所 | 2022-08-30 | — | — | CN | claimed |
| CN-114712541-A | Gilding aroma volatile liquid formula and preparation method thereof | 大连达伦特工艺品有限公司 | 2022-07-08 | — | — | CN | claimed |
| CN-108485411-A | A kind of anti-alkaline etching ground of mechanical processing | 徐州迈斯特机械科技有限公司 | 2018-09-04 | — | — | CN | claimed |
| CN-108014987-A | A kind of anti-alkaline etching ground spraying method of mechanical part | 成都龙泉马龙机械厂 | 2018-05-11 | — | — | CN | claimed |
| CN-107805428-A | One kind is machined anti-alkaline etching ground | 成都龙泉马龙机械厂 | 2018-03-16 | — | — | CN | claimed |
| CN-106590421-A | High-temperature-resistant paint for aeronautical materials and preparation method of high-temperature-resistant paint | 南京悠谷知识产权服务有限公司 | 2017-04-26 | — | — | CN | claimed |
| CN-1109538-C | Buffered emulsion compositions containing active materials susceptible to acid or alkaline hydrolysis | MEDICAL CT OF CHILREN S HOSPIT (US) | 2003-05-28 | — | — | CN | claimed |
| US-4950440-A | Process for the manufacture of high fatty acid monoglyceride monosulfate detergents | COLGATE-PALMOLIVE COMPANY (US) | 1990-08-21 | — | — | US | claimed |