Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12264634 | 0.92 | MMP8 (0.43) | ALDH1A1KDM4EMMP8SMN1; SMN2HSD17B10 | |
| SCHEMBL1432886 | 0.89 | MMP8 (0.45) | ALDH1A1KDM4EMMP8SMN1; SMN2HSD17B10 | |
| Hydrochloric Acid SCHEMBL28191013 | 0.86 | MMP8 (0.43) | ALDH1A1KDM4EMMP8SMN1; SMN2HSD17B10 | |
| SCHEMBL6317495 | 0.84 | MMP8 (0.42) | ALDH1A1KDM4EMMP8SMN1; SMN2HSD17B10 | |
| SCHEMBL7324199 | 0.83 | ALOX5 (0.42) | ALDH1A1KDM4ESMN1; SMN2HSD17B10ALOX5 | |
| Pyridine SCHEMBL28854067 | 0.81 | MMP8 (0.42) | ALDH1A1KDM4EMMP8SMN1; SMN2HSD17B10 | |
| SCHEMBL5143523 | 0.79 | ALDH1A1 (0.46) | ALDH1A1KDM4EMMP8SMN1; SMN2HSD17B10 | |
| SCHEMBL2474796 | 0.79 | NPC1 (0.47) | ALDH1A1MMP8SMN1; SMN2HSD17B10KEAP1 | |
| SCHEMBL26066472 | 0.78 | ALDH1A1 (0.45) | ALDH1A1MMP8HSD17B10KMT2APKM | |
| SCHEMBL3407961 | 0.78 | ALOX5 (0.45) | ALDH1A1KDM4ESMN1; SMN2HSD17B10ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7301031-B2 | Methods for producing hydroxy amino acids, esters, and derivatives thereof | BIOCATALYTICS, INC. (US) | 2007-11-27 | — | — | US | disclosed |
| US-7081535-B2 | Hydroxy-amino acids | BIOCATALYTICS, INC. (US) | 2006-07-25 | — | — | US | disclosed |
| US-20050192439-A1 | Methods for producing hydroxy amino acids, esters, and derivatives thereof | CODEXIS, INC. | 2005-09-01 | — | — | US | disclosed |
| US-20050100993-A1 | Methods for producing hydroxy amino acids and derivatives thereof | BIOCATALYTICS, INC. | 2005-05-12 | — | — | US | disclosed |
| US-6833471-B2 | Contacting beta-ketodiester having ketone and two esters with a ketoreductase under conditions permitting reduction of ketone to alcohol, regioselectively hydrolyzing one of ester groups to acid, converting acid or ester to amine | BIOCATALYTICS, INC. | 2004-12-21 | — | — | US | disclosed |
| US-20040053377-A1 | Methods for producing hydroxy amino acids and derivatives thereof | CODEXIS, INC. | 2004-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040053377-A1 | Methods for producing hydroxy amino acids and derivatives thereof | HMGCR, HSD17B12, BCKDK | ALDH1A1 514/4885KDM4E 507/4885MMP8 2298/4885 |
| US-20050100993-A1 | Methods for producing hydroxy amino acids and derivatives thereof | ALDH7A1, BCKDK, HSD17B12 | ALDH1A1 130/4885KDM4E 167/4885MMP8 2240/4885 |
| US-20050192439-A1 | Methods for producing hydroxy amino acids, esters, and derivatives thereof | ALDH7A1, BCKDK, ADH5 | ALDH1A1 135/4885KDM4E 606/4885MMP8 2236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.