Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.37 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.37 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.37 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.37 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147356 | 0.78 | BCAT2 (0.43) | PTGS2ALDH1A1PTGS1PTPN1 | |
| SCHEMBL15009038 | 0.74 | KEAP1 (0.60) | KDM4ECYP1A2CYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL7502836 | 0.74 | PTGS2 (0.49) | PTGS2MAPTALDH1A1CYP2A6PTGS1 | |
| SCHEMBL7797358 | 0.73 | PTPN1 (0.60) | PTGS2KDM4EALDH1A1ABL1ABCB1 | |
| SCHEMBL19287149 | 0.72 | ALDH1A1 (0.59) | MAPTALDH1A1CYP2A6SMN1; SMN2 | |
| SCHEMBL1515689 | 0.71 | ABL1 (0.50) | MAPTKDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL27538658 | 0.71 | MAPT (0.44) | PTGS2MAPTKDM4ECYP1A2CYP2C9 | |
| SCHEMBL8038496 | 0.71 | PTGS2 (0.51) | PTGS2MAPTALDH1A1PTGS1APP | |
| SCHEMBL1181119 | 0.71 | PTGS2 (0.73) | PTGS2PTGS1 | |
| SCHEMBL9214748 | 0.71 | PTGS2 (0.40) | PTGS2MAPTKDM4EALDH1A1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831207-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006066172-A1 | AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE | AMGEN, INC. (US) | 2006-06-22 | — | — | WO | disclosed |