Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.36 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.36 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.36 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.36 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | TSPO | P30536 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6047897 | 0.86 | GSK3B (0.38) | DRD2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4222368 | 0.83 | PRKAB2 (0.51) | DRD2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4226616 | 0.81 | AQP1 (0.45) | DRD2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4226625 | 0.81 | PRKAB2 (0.42) | DRD2PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4596468 | 0.78 | ALDH1A1 (0.42) | DRD2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL4596465 | 0.77 | ALDH1A1 (0.37) | DRD2MAPTALDH1A1NPC1RAB9A | |
| SCHEMBL5148555 | 0.77 | DRD2 (0.37) | DRD2MAPTALDH1A1HTTTDP1 | |
| SCHEMBL4225733 | 0.75 | ALDH1A1 (0.39) | MAPTALDH1A1GAAHTTTDP1 | |
| SCHEMBL4790525 | 0.75 | AQP1 (0.56) | ALDH1A1NPC1RAB9AF2RL3HRH3 | |
| SCHEMBL4789302 | 0.75 | AQP1 (0.45) | HRH3METAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871354-A1 | TREATMENT OF PAIN | Wyeth (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006116171-A1 | TREATMENT OF PAIN | WYETH (US) | 2006-11-02 | — | — | WO | disclosed |