Hispidulin

Hispidulin

SCHEMBL514926

COc1c(O)cc2oc(-c3ccc(O)cc3)cc(=O)c2c1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 5/20 1.00
MAPT P10636 5/20 1.00
FLT3 P36888 5/20 1.00
KMT2A Q03164 4/20 1.00
MEN1 O00255 3/20 1.00
NPC1 O15118 3/20 1.00
RAB9A P51151 2/20 1.00
GFER P55789 2/20 1.00
GABRP O00591 2/20 1.00
GABRD O14764 2/20 1.00
GABRA1 P14867 2/20 1.00
GABRB1 P18505 2/20 1.00
GABRG2 P18507 2/20 1.00
GABRB3 P28472 2/20 1.00
GABRA5 P31644 2/20 1.00
GABRA3 P34903 2/20 1.00
GABRA2 P47869 2/20 1.00
GABRB2 P47870 2/20 1.00
GABRA4 P48169 2/20 1.00
GABRE P78334 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hispidulin SCHEMBL29458970 1.00 POLB (1.00) POLBMAPTFLT3KMT2AMEN1
Pectolinarigenin SCHEMBL29606971 0.91 MAPT (1.00) POLBMAPTFLT3KMT2AMEN1
Pectolinarigenin SCHEMBL243686 0.91 MAPT (1.00) POLBMAPTFLT3KMT2AMEN1
SCHEMBL30288880 0.90 FLT3 (0.81) POLBMAPTFLT3KMT2AMEN1
SCHEMBL17258304 0.90 FLT3 (0.81) POLBMAPTFLT3KMT2AMEN1
SCHEMBL28978234 0.90 FLT3 (0.81) POLBMAPTFLT3KMT2AMEN1
SCHEMBL737628 0.90 FLT3 (0.81) POLBMAPTFLT3KMT2AMEN1
SCHEMBL28978248 0.90 FLT3 (0.81) POLBMAPTFLT3KMT2AMEN1
Oroxylin A SCHEMBL431423 0.90 CREB1 (1.00) POLBMAPTFLT3KMT2AMEN1
Oroxylin A SCHEMBL30452350 0.90 CREB1 (1.00) POLBMAPTFLT3KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 649 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122031539-A Pine bark polyphenol extract and preparation method and application thereof 北京农学院 2026-05-15 CN claimed
EP-4739147-A1 COMPOSITION Nicoventures Trading Limited (GB) 2026-05-13 EP claimed
US-12594421-B2 Compositions and methods for increasing cancer cell sensitivity to alternating electric fields NOVOCURE GMBH (CH) 2026-04-07 US claimed
EP-4714440-A2 A HEALING HERBAL-MINERAL COMPOSITION WITH ENHANCED EFFECTS Kurek, Janusz (PL) 2026-03-25 EP claimed
EP-4698662-A2 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2026-02-25 EP claimed
EP-4615506-A1 USE OF GSK-3 ACTIVATIOR TO MODULATE PROTEASOME ACTIVITY TO PREVENT AGEING ASSOCIATED CONDITIONS AND DISEASES Sahin, Fikret (TR) 2025-09-17 EP claimed
EP-4599048-A1 COMPOSITIONS AND METHODS FOR SMALL MOLECULE BASED EXPANSION OF PLURIPOTENT STEM CELLS Trailhead Biosystems Inc. (US) 2025-08-13 EP claimed
EP-4569090-A2 METHODS AND COMPOSITIONS FOR GENERATING OLIGODENDROCYTE PROGENITOR CELLS Trailhead Biosystems Inc. (US) 2025-06-18 EP claimed
WO-2024220449-A9 REGULATABLE CONTROLLED EXPRESSION OF A TRANSGENE IN PRIMATES AskBio Inc. (US) 2025-04-03 WO claimed
US-20250051551-A1 IMPROVED POLYMER COMPOSITES WARNER BABCOCK INSTITUTE FOR GREEN CHEMISTRY, LLC (US) 2025-02-13 US claimed
US-20120315332-A1 PHARMACEUTICAL COMPOSITION INCLUDING SUNFLOWER EXTRACT, PREPARATIVE METHOD AND USE THEREOF PEIXUE LING (CN) 2012-12-13 US claimed
EP-2520305-A1 MEDICINAL COMPOSITION INCLUDING SUNFLOWER EXTRACT, PREPARATIVE METHOD AND USE THEREOF Ling, Peixue (CN) 2012-11-07 EP claimed
CN-102018740-B Pharmaceutical composition containing sunflower leaf extract and use thereof PEIXUE LING 2012-05-23 CN claimed
US-20110171193-A1 COMPOSITIONS AND METHODS FOR TREATING PULMONARY HYPERTENSION THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2011-07-14 US claimed
CN-102018740-A Medicinal composition containing extracts of leaves of helianthus and application of the same PEIXUE LING 2011-04-20 CN claimed
WO-2009152453-A2 COMPOSITIONS AND METHODS FOR TREATING PULMONARY HYPERTENSION THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2009-12-17 WO claimed
CN-101538298-A A method for synthesizing 5,6,4'-trihydroxyflavone-7-0-D-glucuronic acid SICHUAN IND I OF ANTIBIOTICS C 2009-09-23 CN claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
EP-1145709-A1 Use of natural products to prepare cosmetic compositions LABORATOIRES SEROBIOLOGIQUES (FR) 2001-10-17 EP claimed
US-4935450-A Cancer therapy system for effecting oncolysis of malignant neoplasms THERAPEUTICAL SYSTEMS CORPORATION (US) 1990-06-19 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12594421-B2 Compositions and methods for increasing cancer cell sensitivity to alternating electric fields PTK2, GSK3B, MTOR POLB 3012/4885MAPT 1987/4885FLT3 669/4885
US-20120315332-A1 PHARMACEUTICAL COMPOSITION INCLUDING SUNFLOWER EXTRACT, PREPARATIVE METHOD AND USE THEREOF HMGCR, LSS, CYP8B1 POLB 3061/4885MAPT 690/4885FLT3 3902/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.