SCHEMBL5154485

SCHEMBL5154485

Cc1cc(C(O)(c2ccc(Cl)cc2)C(F)(F)F)ccc1NC(=O)OC(C)(C)C

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.43
LMNA P02545 3/20 0.43
ALDH1A1 P00352 3/20 0.43
MAPT P10636 2/20 0.43
ALOX12 P18054 2/20 0.43
HPGD P15428 1/20 0.43
MAPK1 P28482 1/20 0.43
PDK1 Q15118 4/20 0.42
PDK2 Q15119 4/20 0.42
PDK3 Q15120 4/20 0.42
PDK4 Q16654 4/20 0.42
RXFP1 Q9HBX9 1/20 0.40
TSHR P16473 1/20 0.40
HTT P42858 1/20 0.40
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
POLB P06746 1/20 0.39
CDC7 O00311 1/20 0.38
EEF2K O00418 1/20 0.38
PLK4 O00444 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5151209 0.87 TRPV1 (0.42) SMN1; SMN2LMNAMAPK1RXFP1NPC1
SCHEMBL5151216 0.86 RXFP1 (0.38) SMN1; SMN2PDK1PDK2PDK3PDK4
SCHEMBL6242304 0.86 KMT2A (0.47) SMN1; SMN2LMNAALDH1A1MAPTALOX12
SCHEMBL5155513 0.83 SMN1; SMN2 (0.39) SMN1; SMN2LMNAALDH1A1MAPTALOX12
SCHEMBL5155508 0.83 SMN1; SMN2 (0.39) SMN1; SMN2LMNAALDH1A1MAPTALOX12
SCHEMBL12387210 0.83 PDK1 (0.55) SMN1; SMN2ALDH1A1MAPTPDK1PDK2
SCHEMBL5731619 0.83 POLB (0.54) SMN1; SMN2ALDH1A1MAPTHPGDMAPK1
SCHEMBL5151689 0.82 ALDH1A1 (0.44) SMN1; SMN2LMNAALDH1A1MAPTALOX12
SCHEMBL6237368 0.82 CYP1A2 (0.41) SMN1; SMN2LMNAALDH1A1MAPTALOX12
SCHEMBL29803307 0.82 RXFP1 (0.55) SMN1; SMN2LMNAMAPTRXFP1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070043011-A1 Substituted benzanilide compound and noxious organism controlling agent MITSUBISHI TANABE PHARMA CORPORATION (JP) 2007-02-22 US disclosed
EP-1671941-A1 SUBSTITUTED BENZANILIDE COMPOUND AND PEST CONTROL AGENT Nissan Chemical Industries, Ltd. (JP) 2006-06-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070043011-A1 Substituted benzanilide compound and noxious organism controlling agent L3MBTL1, L3MBTL3, L3MBTL4 SMN1; SMN2 2170/4885LMNA 1667/4885ALDH1A1 888/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.