Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL142204 | 0.91 | L3MBTL1 (0.64) | L3MBTL1ATMTDP1SIRT1PTGS2 | |
| SCHEMBL31257839 | 0.91 | L3MBTL1 (0.64) | L3MBTL1ATMTDP1SIRT1PTGS2 | |
| SCHEMBL1758192 | 0.80 | CA12 (0.68) | L3MBTL1SIRT1PTGS2MAPTKDM4E | |
| Naphthoquinone SCHEMBL10797978 | 0.78 | PTPRC (0.55) | L3MBTL1ATMTDP1SIRT1PTGS2 | |
| SCHEMBL9217699 | 0.78 | CA1 (0.73) | L3MBTL1ATMTDP1SIRT1PTGS2 | |
| SCHEMBL5476111 | 0.77 | MAPT (0.68) | L3MBTL1TDP1SIRT1PTGS2MAPT | |
| SCHEMBL867944 | 0.76 | VCAM1 (0.69) | L3MBTL1ATMTDP1PTGS2POLB | |
| SCHEMBL5595136 | 0.76 | MAPK1 (0.69) | L3MBTL1ATMTDP1PTGS2MAPT | |
| Benzophenone SCHEMBL28261176 | 0.76 | ALDH1A1 (0.78) | L3MBTL1ATMTDP1MAPTKDM4E | |
| SCHEMBL28409662 | 0.76 | MEN1 (0.72) | L3MBTL1ATMTDP1PTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7282468-B2 | Direct thermographic materials with catechol borate reducing agents | CARESTREAM HEALTH INC. (US) | 2007-10-16 | — | — | US | disclosed |
| US-20070015660-A1 | Direct thermographic materials with catechol borate reducing agents | EASTMAN KODAK COMPANY | 2007-01-18 | — | — | US | disclosed |