Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP46A1 | Q9Y6A2 | 2/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5174941 | 0.83 | IP6K1 (0.38) | CYP2C19CHRM2CYP3A4CYP2C9MEN1 | |
| SCHEMBL5152604 | 0.77 | HDAC1 (0.45) | LMNASMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL1802003 | 0.77 | SMN1; SMN2 (0.50) | CYP2C19SMN1; SMN2CHRM2CYP3A4CYP2D6 | |
| SCHEMBL5151551 | 0.77 | MEN1 (0.51) | SMN1; SMN2MEN1KMT2ACYP2D6RIPK1 | |
| SCHEMBL5155027 | 0.76 | L3MBTL1 (0.44) | SMN1; SMN2MEN1TP53KMT2ATSHR | |
| SCHEMBL1801385 | 0.74 | RIPK1 (0.52) | POLBCYP2C19LMNACHRM2CYP3A4 | |
| SCHEMBL1801939 | 0.73 | OPRD1 (0.47) | LMNACYP3A4CYP2C9CYP2D6TSHR | |
| SCHEMBL1803702 | 0.73 | CYP2C19 (0.43) | POLBCYP2C19PARP1LMNASMN1; SMN2 | |
| SCHEMBL5151635 | 0.73 | KMT2A (0.42) | SMN1; SMN2MEN1TP53KMT2ATSHR | |
| SCHEMBL24106950 | 0.70 | OPRD1 (0.46) | CYP2C19LMNACHRM2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070015784-A1 | Subsitituted 1,4,8- triazaspiro [4,5]decan-2-one compounds | GRUENENTHAL GMBH (DE) | 2007-01-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070015784-A1 | Subsitituted 1,4,8- triazaspiro [4,5]decan-2-one compounds | SI, SSTR4, SLC10A2 | POLB 2915/4885CYP2C19 295/4885PARP1 340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.