Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 4/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 4/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4867137 | 0.87 | KMT2A (0.48) | OPRM1OPRL1EPHX2MEN1KMT2A | |
| SCHEMBL4053293 | 0.84 | KMT2A (0.50) | OPRM1OPRL1EPHX2KMT2AEPHX1 | |
| SCHEMBL2981366 | 0.82 | EPHX2 (0.50) | OPRM1OPRL1EPHX2MEN1KMT2A | |
| SCHEMBL5162372 | 0.81 | RAB9A (0.43) | OPRM1OPRL1MEN1KMT2ANPC1 | |
| SCHEMBL206731 | 0.78 | HDAC3 (0.51) | OPRM1OPRL1EPHX2EPHX1NPC1 | |
| SCHEMBL208660 | 0.78 | PLAAT3 (0.46) | OPRM1OPRL1EPHX2EPHX1NPC1 | |
| SCHEMBL206736 | 0.77 | HPGD (0.48) | OPRM1OPRL1EPHX2MEN1KMT2A | |
| SCHEMBL206079 | 0.76 | OPRM1 (0.54) | OPRM1OPRL1EPHX2EPHX1 | |
| SCHEMBL2985780 | 0.76 | MCHR1 (0.53) | EPHX2MEN1KMT2ATP53TSHR | |
| SCHEMBL2972824 | 0.76 | ATF4 (0.59) | MEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1751090-A1 | ACID DERIVATIVES OF SUBSTITUTED CYCLOHEXYL-1,4-DIAMINES | Grünenthal GmbH (DE) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005110973-A1 | ACID DERIVATIVES OF SUBSTITUTED CYCLOHEXYL-1,4-DIAMINES | Grünenthal GmbH (DE) | 2005-11-24 | — | — | WO | disclosed |