Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.44 |
| ▸ | RELA | Q04206 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7027698 | 0.85 | PRSS1 (0.44) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL5158364 | 0.84 | HCAR2 (0.36) | LMNAHDAC3HDAC1HDAC2MAPT | |
| SCHEMBL5160556 | 0.84 | NAAA (0.43) | LMNAL3MBTL1HDAC3HDAC1HDAC2 | |
| SCHEMBL23926879 | 0.79 | L3MBTL1 (0.54) | LMNAL3MBTL1HDAC3HDAC1HDAC2 | |
| SCHEMBL22361431 | 0.79 | LMNA (0.55) | LMNAL3MBTL1HDAC3HDAC1HDAC2 | |
| SCHEMBL5160652 | 0.78 | GPR84 (0.37) | MAPT | |
| SCHEMBL5162981 | 0.77 | GPR84 (0.34) | MAPTHCAR3 | |
| SCHEMBL9763970 | 0.76 | LMNA (0.56) | LMNAL3MBTL1HDAC3HDAC1HDAC2 | |
| SCHEMBL5158724 | 0.76 | LMNA (0.43) | LMNAL3MBTL1NPC1SMN1; SMN2HTT | |
| SCHEMBL5162412 | 0.75 | MGAM (0.48) | LMNASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1340746-B1 | Process for the reduction of 3-heteroaryl-3-oxo-propanoic acid derivatives | SALTIGO GMBH (DE) | 2007-02-28 | — | — | EP | disclosed |
| EP-1340746-A1 | Process for the reduction of 3-heteroaryl-3-oxo-propanoic acid derivatives | BAYER AG (DE) | 2003-09-03 | — | — | EP | disclosed |