SCHEMBL5160451

SCHEMBL5160451

CCCCC(CC)CC(C(=O)O)C(=O)c1cccnc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.47
LMNA P02545 4/20 0.45
HDAC3 O15379 1/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC2 Q92769 1/20 0.45
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
TSHR P16473 1/20 0.43
CYP2C19 P33261 1/20 0.43
TBXAS1 P24557 4/20 0.43
ALDH1A1 P00352 2/20 0.42
APP P05067 1/20 0.42
GAA P10253 1/20 0.42
HCAR3 P49019 1/20 0.42
HCAR2 Q8TDS4 1/20 0.42
NFKB1 P19838 2/20 0.41
NFKB2 Q00653 2/20 0.41
RELA Q04206 2/20 0.41
NPC1 O15118 1/20 0.41
POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23926879 0.87 L3MBTL1 (0.54) L3MBTL1LMNAHDAC3HDAC1HDAC2
SCHEMBL7027705 0.85 ALDH1A1 (0.48) L3MBTL1LMNAHDAC3HDAC1HDAC2
SCHEMBL5160570 0.84 HDAC3 (0.40) L3MBTL1LMNAHDAC3HDAC1HDAC2
SCHEMBL5158380 0.84 CA2 (0.37) LMNAHDAC3HDAC1HDAC2TSHR
SCHEMBL5162022 0.81 ALDH1A1 (0.55) L3MBTL1LMNAHDAC3HDAC1HDAC2
SCHEMBL7028910 0.78 SLC6A3 (0.45) L3MBTL1LMNAHDAC3HDAC1HDAC2
SCHEMBL5160664 0.78 ALDH1A1 (0.40) L3MBTL1LMNAHDAC3HDAC1HDAC2
SCHEMBL5158739 0.76 GSK3B (0.43) L3MBTL1LMNAHDAC3HDAC1HDAC2
SCHEMBL13822673 0.76 KMT2A (0.59) L3MBTL1HDAC3HDAC1HDAC2CYP1A2
SCHEMBL5162990 0.76 ALDH1A1 (0.36) LMNAHDAC3HDAC1HDAC2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1340746-B1 Process for the reduction of 3-heteroaryl-3-oxo-propanoic acid derivatives SALTIGO GMBH (DE) 2007-02-28 EP disclosed
EP-1340746-A1 Process for the reduction of 3-heteroaryl-3-oxo-propanoic acid derivatives BAYER AG (DE) 2003-09-03 EP disclosed