Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G10 | O15496 | 4/20 | 0.54 |
| ▸ | PLA2G1B | P04054 | 4/20 | 0.54 |
| ▸ | PLA2G2E | Q9NZK7 | 4/20 | 0.54 |
| ▸ | PLA2G2D | Q9UNK4 | 4/20 | 0.54 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.54 |
| ▸ | PLA2G2F | Q9BZM2 | 3/20 | 0.45 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5160095 | 0.83 | PLA2G2A (0.52) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A | |
| SCHEMBL14608034 | 0.82 | ALDH1A1 (0.45) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A | |
| SCHEMBL5162898 | 0.80 | PLA2G10 (0.55) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A | |
| SCHEMBL5160158 | 0.79 | PLA2G10 (0.54) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A | |
| SCHEMBL6335034 | 0.78 | PLA2G2A (0.48) | PLA2G2AMTNR1AMTNR1BBRD4 | |
| SCHEMBL5160134 | 0.78 | KMT2A (0.55) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A | |
| SCHEMBL6279125 | 0.77 | MTNR1A (0.44) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A | |
| SCHEMBL26473 | 0.75 | MTNR1B (0.67) | PLA2G2AMTNR1AMTNR1BKMT2APTGDR2 | |
| SCHEMBL14608169 | 0.74 | PLA2G10 (0.41) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A | |
| SCHEMBL5530394 | 0.71 | PLA2G2A (1.00) | PLA2G10PLA2G1BPLA2G2EPLA2G2DPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1358156-B1 | BENZ(G) INDOLES AND THEIR USE AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2007-02-21 | — | — | EP | disclosed |
| EP-1358156-B1 | BENZ(G) INDOLES AND THEIR USE AS SPLA2 INHIBITORS | LILLY CO ELI (US) | 2007-02-21 | — | — | EP | disclosed |
| US-6916840-B2 | Spla2 inhibitors | ELI LILLY AND COMPANY (US) | 2005-07-12 | — | — | US | disclosed |
| US-20040063967-A1 | Novel spla2 inhibitors | BEIGHT DOUGLAS WADE (US) | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063967-A1 | Novel spla2 inhibitors | PLA2G12A, SPINT2, PLA2G4A | PLA2G10 18/4885PLA2G1B 14/4885PLA2G2E 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.