SCHEMBL5164934

SCHEMBL5164934

Nc1ccc(Cl)cc1C1=CCNC(Cc2ccccc2)C1

nearest known ligand 0.37

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 2/20 0.34
POLB P06746 1/20 0.34
REN P00797 5/20 0.33
TRPM4 Q8TD43 2/20 0.33
TRPM5 Q9NZQ8 2/20 0.33
CTSD P07339 2/20 0.33
CTSE P14091 2/20 0.33
PGC P20142 2/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
IDO1 P14902 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5246489 0.82 CCNT1 (0.37) SLC6A4
SCHEMBL6504166 0.76 POLB (0.34) POLB
SCHEMBL5265951 0.74 POLB (0.44) POLB
SCHEMBL7560334 0.74 POLB (0.39) POLBIDO1
SCHEMBL5543765 0.74 POLB (0.39) POLB
SCHEMBL6506502 0.72 POLB (0.35) POLB
SCHEMBL8368017 0.72 SLC6A3 (0.37) POLBSLC6A2SLC6A4
SCHEMBL4078455 0.71 KDR (0.44)
SCHEMBL7844747 0.71 CDK9 (0.35) HTR2APOLB
Hydrochloric Acid SCHEMBL18304929 0.71 GPBAR1 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1763302-A2 CHEMICAL COMPOUNDS Syngeta Participations AG (CH) 2007-03-21 EP disclosed
WO-2006003494-A2 PIPERIDINE DERIVATIVES AND THEIR USE AS INSECTICIDES, ACARICIDES, MOLLUSCICIDES OR NEMATICIDES SYNGENTA PARTICIPATIONS AG (CH) 2006-01-12 WO disclosed