Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | DDO | Q99489 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8368017 | 0.75 | SLC6A3 (0.37) | KDM4E | |
| SCHEMBL5265951 | 0.72 | POLB (0.44) | — | |
| SCHEMBL7560334 | 0.72 | POLB (0.39) | — | |
| SCHEMBL5164934 | 0.71 | HTR2A (0.34) | — | |
| SCHEMBL9051187 | 0.70 | CHRM2 (0.38) | BRD4 | |
| SCHEMBL6504166 | 0.69 | POLB (0.34) | — | |
| SCHEMBL7844747 | 0.69 | CDK9 (0.35) | — | |
| SCHEMBL8312119 | 0.68 | POLB (0.40) | — | |
| SCHEMBL6683579 | 0.68 | POLB (0.37) | — | |
| SCHEMBL1813854 | 0.67 | KDR (0.60) | KDRCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020470-A2 | CGRP RECEPTOR ANTAGONISTS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-02-12 | — | — | WO | disclosed |