Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3085793 | 0.99 | HRH3 (0.54) | HRH3SIGMAR1OPRM1OPRD1OPRK1 | |
| SCHEMBL3081018 | 0.89 | ALDH1A1 (0.60) | SIGMAR1OPRM1OPRD1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL11194779 | 0.88 | ALDH1A1 (0.59) | SIGMAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5166238 | 0.87 | ALDH1A1 (0.51) | HRH3OPRM1OPRD1OPRK1OPRL1 | |
| Hydrochloric Acid SCHEMBL3098282 | 0.86 | ALDH1A1 (0.50) | HRH3OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL7256584 | 0.84 | SIGMAR1 (0.57) | SIGMAR1OPRL1 | |
| Bromide SCHEMBL7248470 | 0.83 | SIGMAR1 (0.56) | SIGMAR1OPRL1 | |
| SCHEMBL5166185 | 0.83 | ALDH1A1 (0.53) | SIGMAR1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5168106 | 0.82 | OPRM1 (0.60) | OPRM1OPRD1OPRK1OPRL1ALDH1A1 | |
| SCHEMBL5166771 | 0.82 | ALDH1A1 (0.60) | SIGMAR1OPRM1OPRD1OPRK1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1771417-A1 | SUBSTITUTED 3-PHENYLPIPERIDINE DERIVATIVES | Grünenthal GmbH (DE) | 2007-04-11 | — | — | EP | claimed |
| WO-2006010577-A1 | SUBSTITUTED 3-PHENYLPIPERIDINE DERIVATIVES | Grünenthal GmbH (DE) | 2006-02-02 | — | — | WO | claimed |
| EP-1771417-A1 | SUBSTITUTED 3-PHENYLPIPERIDINE DERIVATIVES | Grünenthal GmbH (DE) | 2007-04-11 | — | — | EP | disclosed |
| WO-2006010577-A1 | SUBSTITUTED 3-PHENYLPIPERIDINE DERIVATIVES | Grünenthal GmbH (DE) | 2006-02-02 | — | — | WO | disclosed |