Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3144749 | 0.97 | ALDH1A1 (0.37) | ALDH1A1HPGDHSD17B10TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL5167145 | 0.88 | ENPP3 (0.36) | ALDH1A1HPGDHSD17B10TSHRMAPK1 | |
| SCHEMBL3149399 | 0.85 | ENPP3 (0.38) | ALDH1A1HPGDHSD17B10TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL8674061 | 0.80 | ALDH1A1 (0.38) | ALDH1A1HPGDHSD17B10TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL5170143 | 0.80 | GSTP1 (0.36) | ALDH1A1HPGDHSD17B10TSHRCYP11B1 | |
| Hydrochloric Acid SCHEMBL27530110 | 0.80 | ALDH1A1 (0.36) | ALDH1A1HPGDHSD17B10TSHRMAPK1 | |
| SCHEMBL1452672 | 0.79 | ENPP3 (0.33) | ALDH1A1HPGDHSD17B10TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL3822639 | 0.78 | ADRA2A (0.34) | ALDH1A1HPGDTSHR | |
| SCHEMBL5836701 | 0.78 | RAB9A (0.37) | ALDH1A1HPGDHSD17B10TSHRMAPK1 | |
| Hydrochloric Acid SCHEMBL5168421 | 0.77 | ALDH1A1 (0.36) | ALDH1A1HPGDHSD17B10TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7247686-B2 | Solid cocatalyst component for olefin polymerization and catalyst system thereof | BASELL POLYOLEFINE GMBH (DE) | 2007-07-24 | — | — | US | disclosed |
| EP-1442067-B1 | SOLID COCATALYST COMPONENT FOR OLEFIN POLYMERIZATION AND CATALYST SYSTEM THEREOF | SUNALLOMER LTD (JP) | 2007-04-18 | — | — | EP | disclosed |
| US-20050009689-A1 | Solid cocatalyst component for olefin polymerization and catalyst system thereof | SUNALLOMER LTD. (JP) | 2005-01-13 | — | — | US | disclosed |