Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 7/20 | 0.39 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 2/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15190270 | 0.87 | HSD11B1 (0.41) | HSD11B1OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL2770815 | 0.81 | OPRM1 (0.47) | HSD11B1OPRM1DRD2 | |
| SCHEMBL3905826 | 0.80 | RORC (0.52) | CYP2C19RORCOPRD1OPRK1 | |
| SCHEMBL26927960 | 0.78 | SLC6A3 (0.41) | HSD11B1RORC | |
| SCHEMBL4728073 | 0.75 | HSD11B1 (0.44) | HSD11B1CCR1OPRM1DRD2DRD4 | |
| SCHEMBL4725181 | 0.75 | OPRM1 (0.55) | CCR1OPRM1DRD2DRD4DRD3 | |
| SCHEMBL11098473 | 0.74 | MEN1 (0.34) | HSD11B1 | |
| SCHEMBL3790649 | 0.74 | KMT2A (0.51) | HSD11B1OPRM1S1PR2CYP2C19 | |
| SCHEMBL2428794 | 0.74 | CA12 (0.50) | OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL3428799 | 0.73 | OPRM1 (0.52) | CCR1OPRM1DRD2DRD4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773823-B1 | 4-ARYLMORPHOLIN-3-ONE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2013-08-21 | — | — | EP | disclosed |
| EP-1773823-A1 | 4-ARYLMORPHOLIN-3-ONE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006021654-A1 | 4-ARYLMORPHOLIN-3-ONE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2006-03-02 | — | — | WO | disclosed |