Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5412384 | 0.81 | THRB (0.48) | CYP1A2CYP2C9CYP2C19HTTGRIA2 | |
| SCHEMBL5487948 | 0.80 | THRB (0.46) | CYP1A2CYP2C9CYP2C19HTTGRIA2 | |
| SCHEMBL5485211 | 0.80 | THRB (0.48) | CYP1A2CYP2C9CYP2C19HTTGRIA2 | |
| SCHEMBL5487001 | 0.80 | THRB (0.46) | CYP1A2CYP2C9CYP2C19HTTGRIA2 | |
| SCHEMBL2179051 | 0.79 | GRIA2 (0.45) | CYP1A2CYP2C9CYP2C19HTTGRIA2 | |
| SCHEMBL5184948 | 0.67 | SHMT2 (0.61) | KDM4EMAPTALDH1A1CA12CA1 | |
| SCHEMBL4807734 | 0.66 | KMT2A (0.56) | HTTKDM4EMAPTALDH1A1HSD17B10 | |
| SCHEMBL5185245 | 0.65 | GRIA2 (0.84) | CYP1A2CYP2C9CYP2C19HTTGRIA2 | |
| SCHEMBL5485206 | 0.64 | THRB (0.37) | CYP1A2CYP2C9CYP2C19HTTGRIA2 | |
| SCHEMBL8799669 | 0.64 | CYP1A2 (0.42) | CYP1A2CYP2C9CYP2C19HTTGRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7253161-B2 | Benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2007-08-07 | — | — | US | disclosed |
| US-7250411-B2 | Benzothiazine and benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2007-07-31 | — | — | US | disclosed |
| EP-1456189-B1 | BENZOTHIA(DIA)ZINE DERIVATIVES AND THEIR USE AS AMPA MODULATORS | SERVIER LAB (FR) | 2007-07-04 | — | — | EP | disclosed |
| US-20050124606-A1 | Novel benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2005-06-09 | — | — | US | disclosed |
| US-20050014744-A1 | Benzothiazine and benzothiadiazine compounds | LES LABORATROIRES SERVIER (FR) | 2005-01-20 | — | — | US | disclosed |
| EP-1480986-A1 | NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier (FR) | 2004-12-01 | — | — | EP | disclosed |
| EP-1456189-A1 | BENZOTHIA(DIA)ZINE DERIVATIVES AND THEIR USE AS AMPA MODULATORS | LES LABORATOIRES SERVIER (FR) | 2004-09-15 | — | — | EP | disclosed |
| WO-2003053979-A1 | NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, METHOD FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2003-07-03 | — | — | WO | disclosed |
| WO-2003053947-A1 | BENZOTHIA(DIA)ZINE DERIVATIVES AND THEIR USE AS AMPA MODULATORS | LES LABORATOIRES SERVIER (FR) | 2003-07-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014744-A1 | Benzothiazine and benzothiadiazine compounds | HRH4, NR3C2, HRH3 | CYP1A2 233/4885CYP2C9 509/4885CYP2C19 472/4885 |
| US-20050124606-A1 | Novel benzothiazine and benzothiadiazine derivatives method for preparing same and pharmaceutical compositions containing same | NR4A3, NR5A2, NR4A1 | CYP1A2 141/4885CYP2C9 417/4885CYP2C19 390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.