Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MPO | P05164 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5487948 | 0.87 | THRB (0.46) | THRBCYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL5487001 | 0.87 | THRB (0.46) | THRBCYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL5485206 | 0.85 | THRB (0.37) | THRBCYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL5412384 | 0.85 | THRB (0.48) | THRBCYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL5183853 | 0.80 | CYP1A2 (0.43) | THRBCYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL5349703 | 0.67 | NPSR1 (0.50) | THRBALDH1A1GRIA2MAPTNPSR1 | |
| SCHEMBL5486873 | 0.65 | THRB (0.35) | THRBGRIA2MAPTNPSR1TP53 | |
| SCHEMBL5355691 | 0.64 | GRIA2 (0.43) | THRBCYP1A2ALDH1A1SMN1; SMN2GRIA2 | |
| SCHEMBL2775615 | 0.61 | GRIA2 (0.40) | THRBCYP1A2ALDH1A1SMN1; SMN2GRIA2 | |
| SCHEMBL2775503 | 0.61 | NPSR1 (0.47) | THRBALDH1A1GRIA2MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1655030-B1 | Benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | SERVIER LAB (FR) | 2007-12-19 | — | — | EP | disclosed |
| US-20070270415-A1 | Benzothiadiazine compounds | LESLABORATOIRES SERVIER (FR) | 2007-11-22 | — | — | US | disclosed |
| US-7268130-B2 | Benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2007-09-11 | — | — | US | disclosed |
| US-7262191-B2 | Benzothiadiazine compounds | LES LABORATORIES SERVIER (FR) | 2007-08-28 | — | — | US | disclosed |
| EP-1655299-A1 | Benzothiadiazine derivatives, process of preparation thereof and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2006-05-10 | — | — | EP | disclosed |
| EP-1655030-A1 | Benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | Les Laboratoires Servier (FR) | 2006-05-10 | — | — | EP | disclosed |
| US-20060094713-A1 | New benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2006-05-04 | — | — | US | disclosed |
| US-20060094712-A1 | New benzothiadiazine compounds | LES LABORATOIRES SERVIER (FR) | 2006-05-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270415-A1 | Benzothiadiazine compounds | SLC1A1, SLC1A2, SULT2A1 | THRB 914/4885CYP1A2 210/4885CYP2C9 1358/4885 |
| US-20060094712-A1 | New benzothiadiazine compounds | SLC1A1, SLC1A2, GABRA5 | THRB 917/4885CYP1A2 501/4885CYP2C9 2019/4885 |
| US-20060094713-A1 | New benzothiadiazine compounds | SQOR, NDUFS5, GLRX3 | THRB 1105/4885CYP1A2 565/4885CYP2C9 1535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.