Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5485211 | 0.85 | THRB (0.48) | THRBCYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL5487948 | 0.85 | THRB (0.46) | THRBCYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL5487001 | 0.85 | THRB (0.46) | THRBCYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL5183853 | 0.81 | CYP1A2 (0.43) | THRBCYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL5485206 | 0.69 | THRB (0.37) | THRBCYP1A2CYP2C9CYP2C19HTT | |
| SCHEMBL6413657 | 0.65 | GRIA2 (0.67) | GRIA2 | |
| SCHEMBL2775615 | 0.64 | GRIA2 (0.40) | THRBCYP1A2NPSR1ALDH1A1LMNA | |
| SCHEMBL5349703 | 0.64 | NPSR1 (0.50) | THRBNPSR1ALDH1A1LMNAMAPT | |
| SCHEMBL5184948 | 0.64 | SHMT2 (0.61) | ALDH1A1LMNAMAPTKDM4EKMT2A | |
| SCHEMBL4807734 | 0.63 | KMT2A (0.56) | HTTALDH1A1MAPTKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7262189-B2 | Benzothiazine and benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVER (FR) | 2007-08-28 | — | — | US | disclosed |
| US-20050065146-A1 | Novel benzothiazine and benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | LES LABORATOIRES SERVIER (FR) | 2005-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065146-A1 | Novel benzothiazine and benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same | NR5A2, NR4A3, CBR3 | THRB 1214/4885CYP1A2 151/4885CYP2C9 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.