Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 19/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 10/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4916549 | 0.75 | OPRD1 (0.59) | OPRD1OPRK1OPRM1 | |
| SCHEMBL6032011 | 0.72 | OPRM1 (0.53) | OPRD1OPRK1OPRM1 | |
| SCHEMBL4916048 | 0.66 | OPRM1 (0.59) | OPRM1 | |
| SCHEMBL2527302 | 0.64 | TET3 (0.37) | OPRD1OPRK1OPRM1 | |
| SCHEMBL10925445 | 0.63 | HTR7 (0.40) | — | |
| SCHEMBL8912704 | 0.62 | SIGMAR1 (0.54) | OPRM1 | |
| SCHEMBL4395771 | 0.60 | OPRM1 (0.43) | OPRD1OPRK1OPRM1 | |
| SCHEMBL8351479 | 0.60 | NISCH (0.44) | OPRM1 | |
| SCHEMBL10849119 | 0.59 | GRM1 (0.47) | — | |
| SCHEMBL27999872 | 0.59 | F10 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615644-B1 | SUBSTITUTED 4-PHENYL-4-[1H-IMIDAZOL-2-YL]-PIPERIDINE DERIVATIVES AND THEIR USE AS SELECTIVE NON-PEPTIDE DELTA OPIOID AGONISTS WITH ANTIDEPRESSANT AND ANXIOLYTIC ACTIVITY | JANSSEN PHARMACEUTICA NV (BE) | 2007-02-14 | — | — | EP | disclosed |
| US-20060287345-A1 | Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives as selective non-peptide delta opiod agonists with antidepressant and anxiolytic activity | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287345-A1 | Substituted 4-phenyl-4-[1h-imidazol-2-yl]-piperidine derivatives as selective non-peptide delta opiod agonists with antidepressant and anxiolytic activity | OPRD1, OPRM1, OPRK1 | OPRD1 1/4885OPRK1 3/4885OPRM1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.