Anisole

Anisole

SCHEMBL5188451

COc1ccccc1.COc1ccccc1.O

nearest known ligand 0.93

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Anisole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE known ✓ P22303 2/20 0.50
DRD2 known ✓ P14416 1/20 0.48
DRD4 known ✓ P21917 1/20 0.48
DRD3 known ✓ P35462 1/20 0.48
MEN1 known ✓ O00255 1/20 0.47
CA4 P22748 2/20 0.93
LTA4H P09960 3/20 0.74
CA1 P00915 3/20 0.62
CA2 P00918 3/20 0.62
CA7 P43166 3/20 0.62
CA9 Q16790 3/20 0.62
CA12 O43570 2/20 0.62
CA14 Q9ULX7 2/20 0.62
TRPA1 O75762 1/20 0.56
CES2 O00748 1/20 0.52
CES1 P23141 1/20 0.52
TSHR P16473 1/20 0.50
CYP1A2 P05177 1/20 0.48
CYP2A6 P11509 1/20 0.48
MAPK1 P28482 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Anisole SCHEMBL3840007 1.00
Anisole SCHEMBL2493788 0.97 CA4 (1.00) CA4LTA4HCA1CA2CA7
Anisole SCHEMBL1205 0.97
Anisole SCHEMBL27342302 0.97 CA4 (1.00) CA4LTA4HCA1CA2CA7
Anisole SCHEMBL8472521 0.97 CA4 (1.00) CA4LTA4HCA1CA2CA7
Anisole SCHEMBL10721106 0.97 CA4 (1.00) CA4LTA4HCA1CA2CA7
Anisole SCHEMBL20328417 0.97
Anisole SCHEMBL28813915 0.97 CA4 (1.00) CA4LTA4HCA1CA2CA7
Anisole SCHEMBL30601749 0.97
Anisole SCHEMBL5377903 0.93 CA4 (0.93) CA4LTA4HCA1CA2CA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230339975-A1 CRYSTALLINE FORM OF SHP2 INHIBITOR, AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF ETERN BIOPHARMA (SHANGHAI) CO., LTD. (CN) 2023-10-26 US disclosed
EP-4169920-A1 CRYSTALLINE FORM OF SHP2 INHIBITOR, AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF Etern Biopharma (Shanghai) Co., Ltd. (CN) 2023-04-26 EP disclosed
CN-108701657-B Curable resin composition and fan-out type wafer level package 太阳油墨制造株式会社 2022-05-13 CN disclosed
CN-109836444-B Preparation method of lithium difluoroborate 东莞东阳光科研发有限公司 2021-05-11 CN disclosed
CN-110819263-A Back grinding belt 日东电工株式会社 2020-02-21 CN disclosed
CN-110819249-A Back grinding belt 日东电工株式会社 2020-02-21 CN disclosed
CN-110072696-A Touch sensor assemblies and planarization band 3M创新有限公司 2019-07-30 CN disclosed
CN-108701657-A The wafer-class encapsulation of curable resin constituent and fan-out-type 太阳油墨制造株式会社 2018-10-23 CN disclosed
US-7288557-B2 For preventing or treating proliferative diseases and conditions such as cancer; eg 4-[1,2,3]Triazol-1-yl-1-(4-{2-[(E)-2-(4-trifluoromethoxy-phenyl)-vinyl]-oxazol-4-ylmethoxy}-phenyl)-butan-1-one HOFFMANN-LA ROCHE INC. (US) 2007-10-30 US disclosed
EP-1794153-A1 1,2,3-TRIAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS F. Hoffmann-Roche AG (CH) 2007-06-13 EP disclosed
US-20060211750-A1 Triazole derivatives F. HOFFMANN-LA ROCHE AG (CH) 2006-09-21 US disclosed
WO-2006032453-A1 1,2,3 -TRIAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHITORS F.HOFFMANN-LA ROCHE AG (CH) 2006-03-30 WO disclosed
CN-1688345-A Composition having stabilized redox properties and method of stabilizing redox properties VARDOSANIDZE IRINA VIKTOROVNA (RU) 2005-10-26 CN disclosed
US-4675454-A SULFATED OXIDE OF COPPER, SILVER OR GOLD AS ETHERIFICATION CATALYST AMOCO CORPORATION (US) 1987-06-23 US disclosed
US-4675455-A SULFATED OXIDE OF GROUP 6 METAL CATALYST AMOCO CORPORATION (US) 1987-06-23 US disclosed
US-4675456-A USING SULFATED OXIDE OF LANTHANIDE SERIES; CATALYST ON SUPPORT AMOCO CORPORATION (US) 1987-06-23 US disclosed
US-4638098-A GROUP II B METAL SULFATE CATALYSTS AMOCO CORPORATION (US) 1987-01-20 US disclosed
US-4611084-A Catalytic etherification of phenols to alkyl aryl ethers AMOCO CORPORATION (US) 1986-09-09 US disclosed
US-4124750-A DIENE POLYMER CROSSLINKED WITH A DIHYDRAZIDE COMPOUND THE GOODYEAR TIRE & RUBBER COMPANY (US) 1978-11-07 US disclosed
US-4103077-A Green strength of synthetic elastomers THE GOODYEAR TIRE & RUBBER COMPANY (US) 1978-07-25 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060211750-A1 Triazole derivatives CYP3A43, CYP3A5, CYP11B2 ACHE 3332/4885DRD2 3270/4885DRD4 3057/4885
US-20230339975-A1 CRYSTALLINE FORM OF SHP2 INHIBITOR, AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND USE THEREOF PTPN1, PTPN11, PTPN7 ACHE 4669/4885DRD2 4789/4885DRD4 4794/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.