SCHEMBL5189192

SCHEMBL5189192

CCC1=Cc2c(-c3cccc4ccccc34)cccc2C1[Hf](C)CC[Hf](C)C1C(CC)=Cc2c(-c3cccc4ccccc34)cccc21

nearest known ligand 0.33

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HTR7 P34969 3/20 0.33
HTR1A P08908 2/20 0.32
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
HPGD P15428 1/20 0.31
KMT2A Q03164 1/20 0.31
SLC6A4 P31645 5/20 0.31
DRD2 P14416 1/20 0.31
CYP2D6 P10635 1/20 0.30
SLC6A2 P23975 1/20 0.30
SLC6A3 Q01959 1/20 0.30
PPARG P37231 1/20 0.30
PPARA Q07869 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20815319 0.84 HTR7 (0.33) HTR7HTR1ASLC6A4DRD2
SCHEMBL5189223 0.83 PDCD1 (0.33)
Hydrochloric Acid SCHEMBL7936598 0.82 HTR7 (0.32) HTR7HTR1AMEN1ALDH1A1MAPT
SCHEMBL5859330 0.80 SLC6A4 (0.34) HTR7HTR1AMEN1ALDH1A1MAPT
SCHEMBL8613248 0.79 SLC6A4 (0.34) HTR7HTR1AMEN1ALDH1A1MAPT
SCHEMBL27559648 0.79 SLC6A4 (0.33) HTR7HTR1AMEN1ALDH1A1MAPT
SCHEMBL4622630 0.79 SLC6A4 (0.34) HTR7HTR1AMEN1ALDH1A1MAPT
Hydrochloric Acid SCHEMBL4065888 0.77 HTR7 (0.35) HTR7HTR1AALDH1A1MAPTHPGD
SCHEMBL5836023 0.76 ALOX15 (0.35) HTR7ALDH1A1MAPTHPGDSLC6A4
Hydrochloric Acid SCHEMBL2522717 0.76 HTR7 (0.33) HTR7HTR1AALDH1A1MAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0824113-B2 Supported catalyst, process for its preparation and its use in olefin polymerization BASELL POLYOLEFINE GMBH (DE) 2012-06-27 EP disclosed
EP-0811627-B1 Neutral or ionic compound suitable as catalyst component for olefin polymerization BASELL POLYOLEFINE GMBH (DE) 2007-07-25 EP disclosed
EP-0824112-B1 Supported chemical compound BASELL POLYOLEFINE GMBH (DE) 2006-05-10 EP disclosed
EP-0824113-B1 Supported catalyst, process for its preparation and its use in olefin polymerization BASELL POLYOLEFINE GMBH (DE) 2001-06-20 EP disclosed
EP-0824112-A1 Supported chemical compound HOECHST AKTIENGESELLSCHAFT (DE) 1998-02-18 EP disclosed
EP-0824113-A1 Supported catalyst, process for its preparation and its use in olefin polymerization HOECHST AKTIENGESELLSCHAFT (DE) 1998-02-18 EP disclosed
EP-0811627-A2 Neutral or ionic compound suitable as catalyst component for olefin polymerization HOECHST AKTIENGESELLSCHAFT (DE) 1997-12-10 EP disclosed