Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5193163 | 0.77 | SMN1; SMN2 (0.44) | MAPK1LMNAL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL5195629 | 0.77 | NPC1 (0.39) | TSHRGAAMAPK1LMNANPC1 | |
| SCHEMBL5207365 | 0.75 | LMNA (0.41) | MAPK1LMNAL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL5190136 | 0.72 | EPHX2 (0.52) | TSHRGAAHTTALDH1A1MEN1 | |
| SCHEMBL5190544 | 0.71 | ALDH1A1 (0.56) | MAPK1LMNAL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL5190656 | 0.70 | KMT2A (0.53) | MAPK1L3MBTL1KDM4ENPC1ALDH1A1 | |
| SCHEMBL5191068 | 0.69 | LMNA (0.44) | MAPK1LMNAL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL5192869 | 0.69 | OPRK1 (0.46) | MAPK1LMNAL3MBTL1MEN1KMT2A | |
| SCHEMBL5195061 | 0.67 | SIGMAR1 (0.49) | L3MBTL1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL14371828 | 0.66 | MAPK1 (0.57) | MAPK1LMNAL3MBTL1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |